node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
YPO0945 | YPO0946 | YPO0945 | YPO0946 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | 0.936 |
YPO0945 | YPO2295 | YPO0945 | YPO2295 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | 0.932 |
YPO0945 | b0125 | YPO0945 | YPO3408 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | 0.938 |
YPO0945 | dga | YPO0945 | YPO3909 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative glutamate racemase; Provides the (R)-glutamate required for cell wall biosynthesis. | 0.921 |
YPO0945 | gpp | YPO0945 | YPO3225 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.946 |
YPO0945 | guaA | YPO0945 | YPO2870 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.980 |
YPO0945 | guaB | YPO0945 | YPO2871 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.956 |
YPO0945 | ndk | YPO0945 | YPO2883 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Nucleoside diphosphate kinase; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.959 |
YPO0945 | rph | YPO0945 | YPO0044 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Ribonuclease PH; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. | 0.983 |
YPO0945 | surE | YPO0945 | YPO3358 | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | Stationary-phase survival protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.934 |
YPO0946 | YPO0945 | YPO0946 | YPO0945 | Putative oxygen-independent coproporphyrinogen III oxidase; Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. Belongs to the anaerobic coproporphyrinogen-III oxidase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.936 |
YPO2295 | YPO0945 | YPO2295 | YPO0945 | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.932 |
YPO2295 | gpp | YPO2295 | YPO3225 | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.934 |
YPO2295 | guaA | YPO2295 | YPO2870 | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.941 |
YPO2295 | guaB | YPO2295 | YPO2871 | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.966 |
YPO2295 | surE | YPO2295 | YPO3358 | Haloacid dehalogenase-like hydrolase family protein; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa; Similar to Vibrio cholerae hypothetical protein VCA0608 TR:Q9KLY3 (EMBL:AE004391) (224 aa) fasta scores: E(): 0, 62.9% id in 224 aa, and to Escherichia coli hypothetical protein YjjG SW:YJJG_ECOLI (P33999) (225 aa) fasta scores: E(): 0, 56.8% id in 222 aa. | Stationary-phase survival protein; Nucleotidase with a broad substrate specificity as it can dephosphorylate various ribo- and deoxyribonucleoside 5'-monophosphates and ribonucleoside 3'-monophosphates with highest affinity to 3'-AMP. Also hydrolyzes polyphosphate (exopolyphosphatase activity) with the preference for short-chain-length substrates (P20-25). Might be involved in the regulation of dNTP and NTP pools, and in the turnover of 3'-mononucleotides produced by numerous intracellular RNases (T1, T2, and F) during the degradation of various RNAs. | 0.945 |
b0125 | YPO0945 | YPO3408 | YPO0945 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Conserved hypothetical protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family. | 0.938 |
b0125 | gpp | YPO3408 | YPO3225 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Xanthine-guanine phosphoribosyltransferase; Acts on guanine, xanthine and to a lesser extent hypoxanthine; Belongs to the purine/pyrimidine phosphoribosyltransferase family. XGPT subfamily. | 0.955 |
b0125 | guaA | YPO3408 | YPO2870 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Putative GMP synthase; Catalyzes the synthesis of GMP from XMP. | 0.965 |
b0125 | guaB | YPO3408 | YPO2871 | Similar to Escherichia coli hypoxanthine phosphoribosyltransferase Hpt or B0125 SW:HPRT_ECOLI (P36766) (182 aa) fasta scores: E(): 0, 87.1% id in 178 aa,and to Salmonella typhimurium hypoxanthine phosphoribosyltransferase Hpt SW:HPRT_SALTY (O33799) (178 aa) fasta scores: E(): 0, 87.6% id in 178 aa; Belongs to the purine/pyrimidine phosphoribosyltransferase family. | Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family. | 0.948 |