Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
clpB3Clp ATPase; Similar to Escherichia coli ClpB protein, which is thought to form part of a multi-chaperone system supressing protein aggregation, SW:CLPB_ECOLI (P03815) (857 aa) fasta scores: E(): 0, 39.4% identity in 872 aa overlap and Yersinia enterocolitica Clp protease-associated protein ClpB TR:AAG00524 (EMBL:AF285784) (890 aa) fasta scores: E(): 0, 43.2% id in 876 aa. Similar to YPO1471 (95.0% identity in 879 aa overlap); Belongs to the ClpA/ClpB family. (882 aa)    
Predicted Functional Partners:
clpP
ATP-dependent Clp protease proteolytic subunit ClpP; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family.
  
 
 0.911
dnaK
Chaperone protein DnaK; Acts as a chaperone; Belongs to the heat shock protein 70 family.
  
 
 0.890
YPO0970
Similar to Pseudomonas aeruginosa conserved hypothetical protein TR:AAG03485 (EMBL:AE004448) (741 aa) fasta scores: E(): 3.9e-22, 24.1% id in 771 aa, and to the N-terminal region of Escherichia coli hypothetical protein VgrE TR:O52660 (EMBL:AF044499) (702 aa) fasta scores: E(): 1.5e-19, 22.1% id in 721 aa. Similar to YPO1472 (94.6% identity in 782 aa overlap), YPO0962 (87.2% identity in 211 aa overlap) and YPO0967 (90.0% identity in 211 aa overlap).
 
  
 0.844
dnaJ
Chaperone protein DnaJ; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, D [...]
  
 
 0.821
htpG
Heat shock protein HtpG; Molecular chaperone. Has ATPase activity.
  
 
 0.817
clpS
Conserved hypothetical protein; Involved in the modulation of the specificity of the ClpAP- mediated ATP-dependent protein degradation; Belongs to the ClpS family.
  
 
 0.812
grpE
Heat shock protein GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP- [...]
  
 
 0.798
hsc
Chaperone protein HscA; Chaperone involved in the maturation of iron-sulfur cluster- containing proteins. Has a low intrinsic ATPase activity which is markedly stimulated by HscB. Involved in the maturation of IscU (By similarity).
  
 
 0.785
YPO2840
Putative heat shock protein; Similarity to an internal region of Methanosarcina thermophila heat shock protein 70 Hsp70 TR:Q9UXR0 (EMBL:Y17862) (610 aa) fasta scores: E(): 1.6e-06, 25.3% id in 359 aa. Full length CDS is similar to Escherichia coli hypothetical protein YegD SW:YEGD_ECOLI (P36928) (450 aa) fasta scores: E(): 0, 71.8% id in 450 aa.
  
 
 0.778
hslT
Heat shock protein; Associates with aggregated proteins, together with IbpB, to stabilize and protect them from irreversible denaturation and extensive proteolysis during heat shock and oxidative stress. Aggregated proteins bound to the IbpAB complex are more efficiently refolded and reactivated by the ATP-dependent chaperone systems ClpB and DnaK/DnaJ/GrpE. Its activity is ATP-independent.
  
 
 0.773
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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