STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YPO1000Putative drug efflux protein; Similar to Escherichia coli acriflavin resistance protein A AcrA SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 1.9e-31, 32.8% id in 348 aa, and to Pseudomonas aeruginosa multidrug efflux system protein MexE TR:P95421 (EMBL:X99514) (414 aa) fasta scores: E(): 2e-26,30.5% id in 370 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (425 aa)    
Predicted Functional Partners:
YPO1001
Putative integral membrane efflux protein; Many paralogues within Yersinia pestis eg. YPO3133 fasta scores: E(): 0, 40.1% identity in 1054 aa. Similar to Pseudomonas aeruginosa multidrug resistance protein MexB SW:MEXB_PSEAE (P52002) (1046 aa) fasta scores: E(): 0,40.3% id in 1046 aa, and to Campylobacter jejuni transmembrane efflux protein Cj0366c TR:Q9PID6 (EMBL:AL139075) (1040 aa) fasta scores: E(): 0, 38.5% id in 1037 aa.
 
 0.985
YPO3482
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein B AcrB or AcrE SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 0, 57.8% id in 1040 aa, and to Escherichia coli acriflavin resistance protein F AcrF or EnvD SW:ACRF_ECOLI (P24181) (1034 aa) fasta scores: E(): 0,56.6% id in 1033 aa, and to Pseudomonas aeruginosa multidrug resistance protein MexB or Pa0426 TR:AAG03815 (EMBL:L11616) (1046 aa) fasta scores: E(): 0, 56.1% id in 1034 aa. Similar to YPO3133 (57.8% identity in 1044 aa overlap) and to YPO3043 (58.4% identity in 1035 aa overlap).
  
 0.963
YPO3043
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein D AcrD SW:ACRD_ECOLI (P24177) (1037 aa) fasta scores: E(): 0, 79.5% id in 1036 aa, and to Escherichia coli acriflavin resistance protein B AcrB SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 0, 68.0% id in 1033 aa, and to Escherichia coli acriflavin resistance protein F AcrF or EnvD SW:ACRF_ECOLI (P24181) (1034 aa) fasta scores: E(): 0, 65.0% id in 1034 aa. Similar to YPO3133 (66.5% identity in 1032 aa overlap) and YPO3482 (58.4% identity in 1035 aa overlap).
  
 0.962
acrB
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein B AcrB or AcrE SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 0, 84.1% id in 1047 aa, and to Pseudomonas aeruginosa multidrug resistance protein mMxB or Pa0426 SW:MEXB_PSEAE (P52002) (1046 aa) fasta scores: E(): 0, 68.3% id in 1033 aa. Similar to YPO3043 (66.5% identity in 1032 aa overlap) and to YPO3482 (57.8% identity in 1044 aa overlap).
  
 0.947
ibeB
Similar to Escherichia coli probable outer membrane lipoprotein IbeB precursor SW:IBEB_ECOLI (P77211) (457 aa) fasta scores: E(): 0, 38.8% id in 464 aa, and to Pseudomonas aeruginosa outer membrane protein OprM precursor or OprK or Pa0427 TR:AAG03816 (EMBL:L23839) (485 aa) fasta scores: E(): 0, 48.0% id in 469 aa.
 
 0.937
macB1
Putative ABC transporter ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.925
macB2
Putative ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.925
hasF
Similar to Serratia marcescens haemophore (HasA) ABC-transporter outer membrane component, HasF TR:Q54452 (EMBL:X98513) (500 aa) fasta scores: E(): 0, 76.7% id in 455 aa, and to Escherichia coli ABC-transporter outer membrane protein, TolC SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 73.2% id in 470 aa.
 
 0.848
yegN
AcrB/AcrD/AcrF family membrane protein; Similar to Pseudomonas aeruginosa multidrug efflux transporter AmrB TR:AAG05406 (EMBL:AF147719) (1045 aa) fasta scores: E(): 0, 29.8% id in 1053 aa, and to Escherichia coli hypothetical protein YegN SW:YEGN_ECOLI (P76398) (1040 aa) fasta scores: E(): 0, 81.4% id in 1039 aa. Similar to YPO2849 (50.5% identity in 1018 aa overlap); Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
  
 0.847
YPO0421
Putative multi-drug efflux protein; Similar to Vibrio cholerae transporter, AcrB/D/F family Vc1757 TR:Q9KR85 (EMBL:AE004253) (1016 aa) fasta scores: E(): 4.3e-157, 40.766% id in 1018 aa, and to Xylella fastidiosa cation efflux system protein Xf2083 TR:Q9PBQ7 (EMBL:AE004023) (1020 aa) fasta scores: E(): 2.1e-106, 30.731% id in 999 aa; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
  
 0.845
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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