Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-expression
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[Homology]
Score
sdhASimilar to Escherichia coli succinate dehydrogenase flavoprotein subunit SdhA SW:DHSA_ECOLI (P10444) (588 aa) fasta scores: E(): 0, 92.0% id in 588 aa, and to Vibrio cholerae succinate dehydrogenase, flavoprotein subunit VC2089 TR:Q9KQB1 (EMBL:AE004283) (588 aa) fasta scores: E(): 0, 82.3% id in 588 aa; Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. (588 aa)    
Predicted Functional Partners:
b4153
Similar to Escherichia coli fumarate reductase iron-sulfur protein FrdB SW:FRDB_ECOLI (P00364) (243 aa) fasta scores: E(): 0, 85.5% id in 242 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.999
cybA
Similar to Escherichia coli succinate dehydrogenase cytochrome b556 subunit SdhC SW:DHSC_ECOLI (P10446) (129 aa) fasta scores: E(): 0, 77.2% id in 127 aa, and to Vibrio cholerae succinate dehydrogenase, cytochrome b556 subunit VC2091 TR:Q9KQA9 (EMBL:AE004283) (130 aa) fasta scores: E(): 0, 75.0% id in 124 aa.
 
 0.999
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
 
 0.999
sdhB
Similar to Escherichia coli succinate dehydrogenase iron-sulfur protein SdhB SW:DHSB_ECOLI (P07014) (238 aa) fasta scores: E(): 0, 90.8% id in 238 aa, and to Vibrio cholerae succinate dehydrogenase, iron-sulfur protein VC2088 TR:Q9KQB2 (EMBL:AE004283) (236 aa) fasta scores: E(): 0, 80.2% id in 237 aa; Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.
 
 0.999
b0728
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
 
 0.997
sucD
succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit.
 
 0.997
fumA
Fumarate hydratase, class I; Catalyzes the reversible hydration of fumarate to (S)-malate. Belongs to the class-I fumarase family.
  
 
 0.997
nifJ
Similar to Escherichia coli probable pyruvate-flavodoxin oxidoreductase YdbK SW:NIFJ_ECOLI (P52647) (1174 aa) fasta scores: E(): 0, 80.5% id in 1177 aa, and to Klebsiella pneumoniae pyruvate-flavodoxin oxidoreductase NifJ SW:NIFJ_KLEPN (P03833) (1171 aa) fasta scores: E(): 0, 48.0% id in 1184 aa.
  
 0.996
fumC
Fumarate hydratase, class II; Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
 
 0.994
b4152
Fumarate reductase hydrophobic protein; Seems to be involved in the anchoring of the catalytic components of the fumarate reductase complex to the cytoplasmic membrane.
  
 0.993
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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