STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nfoEndonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. (285 aa)    
Predicted Functional Partners:
xth
Similar to Escherichia coli exodeoxyribonuclease III XthA SW:EX3_ECOLI (P09030) (268 aa) fasta scores: E(): 0,80.1% id in 266 aa, and to Salmonella typhimurium exodeoxyribonuclease III XthA SW:EX3_SALTY (Q9Z612) (268 aa) fasta scores: E(): 0, 78.6% id in 266 aa.
   
 0.933
nth
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
  
 
 0.845
ung
Putative uracil-DNA glycosylase; Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.
  
 
 0.721
dinA
DNA polymerase II; Similar to Escherichia coli DNA damage-inducible DNA polymerase II PolB SW:DPO2_ECOLI (P21189) (782 aa) fasta scores: E(): 0, 72.4% id in 783 aa, and to Pseudomonas aeruginosa DNA polymerase II PolB TR:AAG05275 (EMBL:AE004614) (787 aa) fasta scores: E(): 0, 74.4% id in 785 aa.
    
 
 0.706
YPO1834
Putative glycosidase; Similar to Schizosaccharomyces pombe DNA-3-methyladenine glycosylase Mag1 SW:MAG1_SCHPO (Q92383) (228 aa) fasta scores: E(): 8.1e-13, 30.8% id in 195 aa,and to Deinococcus radiodurans putative DNA-3-methyladenine glycosidase II DR2584 TR:Q9RRB0 (EMBL:AE002087) (225 aa) fasta scores: E(): 1.9e-21, 38.9% id in 193 aa.
    
 
 0.660
sodA
Superoxide dismutase [Mn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.640
hisB
Similar to Escherichia coli histidinol-phosphatase and imidazoleglycerol-phosphate dehydratase HisB TR:Q9S5G5 (P06987) (355 aa) fasta scores: E(): 0, 81.4% id in 355 aa,and to Salmonella typhimurium histidine biosynthesis bifunctional protein HisB [includes: histidinol-phosphatase HisB SW:HIS7_SALTY (P10368) (354 aa) fasta scores: E(): 0,78.9% id in 355 aa.
   
 
 0.574
sodB
Superoxide dismutase [Fe]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family.
  
  
 0.535
argR
Arginine repressor; Regulates arginine biosynthesis genes.
      
 0.533
YPO1307
Putative membrane protein; Similar to Escherichia coli hypothetical protein YeiH SW:YEIH_ECOLI (P33019) (349 aa) fasta scores: E(): 0,66.4% id in 339 aa, and to Neisseria meningitidis hypothetical inner membrane protein NMA0465 TR:Q9JWA8 (EMBL:AL162753) (338 aa) fasta scores: E(): 0, 49.9% id in 339 aa.
       0.529
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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