Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
astESuccinylglutamate desuccinylase; Transforms N(2)-succinylglutamate into succinate and glutamate; Belongs to the AspA/AstE family. Succinylglutamate desuccinylase subfamily. (330 aa)    
Predicted Functional Partners:
astD
Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
 
 
 0.997
astB
Succinylarginine dihydrolase; Catalyzes the hydrolysis of N(2)-succinylarginine into N(2)- succinylornithine, ammonia and CO(2).
 
  
 0.996
astA
Arginine N-succinyltransferase; Catalyzes the transfer of succinyl-CoA to arginine to produce N(2)-succinylarginine.
 
  
 0.989
argM
Succinylornithine aminotransferase; Catalyzes the transamination of N(2)-succinylornithine and alpha-ketoglutarate into N(2)-succinylglutamate semialdehyde and glutamate. Can also act as an acetylornithine aminotransferase. Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. AstC subfamily.
 
  
 0.935
poaA
Bifunctional PutA protein [includes: proline dehydrogenase and delta-1-pyrroline-5-carboxylate; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family.
     
  0.920
aspB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB or AspB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 87.4% id in 1497 aa, and to Vibrio cholerae glutamate synthase, large subunit Vc2376 TR:Q9KPJ1 (EMBL:AE004308) (1487 aa) fasta scores: E(): 0, 73.7% id in 1488 aa.
     
  0.920
gdhA
Similar to Escherichia coli NADP-specific glutamate dehydrogenase GdhA SW:DHE4_ECOLI (P00370) (447 aa) fasta scores: E(): 0, 83.9% id in 447 aa, and to Salmonella typhimurium NADP-specific glutamate dehydrogenase GdhA SW:DHE4_SALTY (P15111) (447 aa) fasta scores: E(): 0, 84.1% id in 447 aa; Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
    
  0.901
glnA
Glutamine synthetase; Highly similar to Escherichia coli glutamine synthetase GlnA SW:GLNA_ECOLI (P06711) (468 aa) fasta scores: E(): 0, 91.5% id in 468 aa.
     
  0.897
glsA1
Similar to Escherichia coli hypothetical protein YggN SW:YGGN_ECOLI (P46143) (239 aa) fasta scores: E(): 0,60.6% id in 231 aa, and to Vibrio cholerae hypothetical protein VC2286 TR:Q9KPS6 (EMBL:AE004299) (256 aa) fasta scores: E(): 0.00045, 26.1% id in 241 aa. Contains a frameshift after codon 166. Frame shift occurs at a poly A pentamer. The sequence has been checked and is believed to be correct; Belongs to the glutaminase family.
     
  0.897
proA
Gamma-glutamyl phosphate reductase; Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
     
  0.897
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
Server load: low (12%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.