STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YPO1981Putative coenzyme synthetase; Similar to Methanobacterium thermoautotrophicum coenzyme F390 synthetase III Mth161 TR:O26263 (EMBL:AE000804) (434 aa) fasta scores: E(): 0.00035, 21.2% id in 448 aa, and to Vibrio cholerae CapK protein, putative Vc0924 TR:Q9KTH8 (EMBL:AE004175) (446 aa) fasta scores: E(): 1.9e-08, 24.4% id in 336 aa. (428 aa)    
Predicted Functional Partners:
YPO1980
Previously sequenced as Yersinia pestis hypothetical protein TR:Q9ZC82 (EMBL:AL031866) (268 aa) fasta scores: E(): 0, 100.0% id in 268 aa. Similar to Xanthomonas campestris hypothetical protein GumP TR:O34267 (EMBL:U70053) (282 aa) fasta scores: E(): 1.4e-22, 33.7% id in 252 aa.
 
     0.953
YPO1979
Similar to Salmonella typhimurium 3-oxoacyl-[acyl-carrier-protein] synthase III SW:FABH_SALTY (O85139) (317 aa) fasta scores: E(): 2.4e-21, 29.0% id in 314 aa, and to Xanthomonas campestris GumO TR:O34266 (EMBL:U70053) (435 aa) fasta scores: E(): 0, 38.3% id in 329 aa, and identical over its N-terminal and C-terminal regions to the previously sequenced Yersinia pestis Q9ZC79 and Q9ZC80, respectively. There is a possible frameshift mutation following codon 158. The sequence has been checked and is believed to be correct.
 
     0.927
YPO2577
Putative aldehyde dehydrogenase; Similar to Streptomyces coelicolor methylmalonic acid semialdehyde dehydrogenase MsdA TR:Q53935 (EMBL:L48550) (500 aa) fasta scores: E(): 0, 55.3% id in 503 aa, and to Pseudomonas aeruginosa probable aldehyde dehydrogenase PA0130 TR:AAG03520 (EMBL:AE004451) (497 aa) fasta scores: E(): 0, 59.4% id in 507 aa.
 
 
 0.794
adhE
Similar to Escherichia coli aldehyde-alcohol dehydrogenase AdhE SW:ADHE_ECOLI (P17547) (890 aa) fasta scores: E(): 0, 90.7% id in 891 aa, and to Vibrio cholerae alcohol dehydrogenase/acetaldehyde dehydrogenase VC2033 TR:Q9KQG5 (EMBL:AE004277) (894 aa) fasta scores: E(): 0,77.0% id in 896 aa; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.
   
 0.779
betB
Betaine aldehyde dehydrogenase; Involved in the biosynthesis of the osmoprotectant glycine betaine. Catalyzes the reversible oxidation of betaine aldehyde to the corresponding acid.
   
 0.766
YPO1290
Putative aldehyde dehydrogenase; Similar to Escherichia coli succinate-semialdehyde dehydrogenase GabD SW:GABD_ECOLI (P25526) (482 aa) fasta scores: E(): 0, 43.4% id in 470 aa, and to Pseudomonas aeruginosa succinate-semialdehyde dehydrogenase GabD TR:AAG03654 (EMBL:AE004464) (483 aa) fasta scores: E(): 0,43.3% id in 487 aa.
   
 0.766
hpaE
4-hydroxyphenylacetate degradation bifunctional isomerase/decarboxylase (pseudogene); Pfam match to entry PF01557 FAA_hydrolase,Fumarylacetoacetate (FAA) hydrolase family, score 273.20,E-value 3.3e-78; Belongs to the aldehyde dehydrogenase family.
   
 0.766
astD
Succinylglutamic semialdehyde dehydrogenase; Catalyzes the NAD-dependent reduction of succinylglutamate semialdehyde into succinylglutamate.
   
 0.766
irp1
Previously sequenced as Yersinia pestis yersiniabactin biosynthetic protein Irp1 TR:Q9Z373 (EMBL:AL031866) (3163 aa) fasta scores: E(): 0, 100.0% id in 3163 aa. Similar to Yersinia enterocolitica HMWP1 protein Irp1 TR:O54511 (EMBL:Y12527) (3161 aa) fasta scores: E(): 0, 97.9% id in 3163 aa.
  
  
 0.727
YPO1982
Putative dehydrogenase; Similar to Pseudomonas aeruginosa WbpK TR:P72144 (EMBL:U50396) (320 aa) fasta scores: E(): 2.8e-07, 29.8% id in 258 aa, and to Pseudomonas aeruginosa WbjfT TR:Q9KIC7 (EMBL:AF236052) (301 aa) fasta scores: E(): 7.7e-07, 27.0% id in 270 aa, and to Yersinia enterocolitica putative 6-deoxy-gulose synthetase-2 WbcB TR:Q56863 (EMBL:U46859) (292 aa) fasta scores: E(): 4e-06, 27.0% id in 256 aa. Proteins WbpK and WbjfT from P.aeruginosa and WbcB from Y. enterocolitica are all involved in O antigen biosynthesis.
 
     0.690
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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