STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prmCPutative protoporphyrinogen oxidase; Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif; Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily. (276 aa)    
Predicted Functional Partners:
prfA
Peptide chain release factor 1; Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.
 
 
 0.996
YPO2019
Putative membrane protein; Similar to Salmonella typhimurium hypothetical protein TR:Q9XCQ2 (EMBL:AF134855) (129 aa) fasta scores: E(): 4.6e-23, 56.3% id in 126 aa, and to Escherichia coli hypothetical protein TR:Q46755 (EMBL:U18555) (130 aa) fasta scores: E(): 3.6e-19, 50.8% id in 120 aa. The S. typhimurium protein has been shown to contribute to Salmonella pathogenicity island 1 (SPI1) gene transcription.
  
    0.896
hemA
glutamyl-tRNA reductase; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
     
 0.737
ftsJ
Ribosomal RNA large subunit methyltransferase J; Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit.
  
   
 0.677
YPO2020
Similar to Salmonella typhimurium hypothetical protein YchA TR:Q9XCQ1 (EMBL:AF134855) (269 aa) fasta scores: E(): 0, 63.6% id in 269 aa, and to Escherichia coli hypothetical protein YchA SW:YCHA_ECOLI (P20101) (269 aa) fasta scores: E(): 0, 61.7% id in 269 aa. The S. typhimurium protein has been shown to contribute to Salmonella pathogenicity island 1 (SPI1) gene transcription.
       0.641
rumC
Putative DNA recombination protein; Involved in DNA recombination.
     
 0.625
YPO2212
Similar to Escherichia coli hypothetical protein YciO SW:YCIO_ECOLI (P45847) (206 aa) fasta scores: E(): 0,80.0% id in 205 aa, and to Vibrio cholerae hypothetical protein VC1178 vc1178 TR:Q9KSS8 (EMBL:AE004197) (206 aa) fasta scores: E(): 0, 74.3% id in 206 aa; Belongs to the SUA5 family.
 
  
 0.623
gcvP
Glycine dehydrogenase; The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein; Belongs to the GcvP family.
     
  0.605
metH
5-Methyltetrahydrofolate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from methyl- cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.
     
  0.592
YPO3261
Probable amidase; Similar to Mycobacterium smegmatis nicotinamidase/pyrazinamidase PzaA TR:Q9ZHK8 (EMBL:AF058285) (468 aa) fasta scores: E(): 0, 34.4% id in 453 aa, and to Rhodococcus sp. enantiomerase-selective amidase AmdA TR:Q53116 (EMBL:M74531) (462 aa) fasta scores: E(): 0, 33.8% id in 461 aa.
   
    0.584
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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