STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
YPO2159Similar to Escherichia coli hypothetical protein YeaC SW:YEAC_ECOLI (P76231) (90 aa) fasta scores: E(): 7.7e-23, 70.7% id in 82 aa, and to Vibrio cholerae hypothetical protein VC1996 TR:Q9KQK2 (EMBL:AE004274) (95 aa) fasta scores: E(): 1.5e-16, 46.2% id in 91 aa. (90 aa)    
Predicted Functional Partners:
msrB
Similar to Escherichia coli hypothetical protein YeaA SW:YEAA_ECOLI (P39903) (137 aa) fasta scores: E(): 0,69.3% id in 137 aa, and to Pasteurella multocida hypothetical protein PM0923 TR:AAK03007 (EMBL:AE006131) (130 aa) fasta scores: E(): 4.1e-32, 57.1% id in 126 aa; Belongs to the MsrB Met sulfoxide reductase family.
  
    0.946
sdhD
Succinate dehydrogenase hydrophobic membrane anchor protein; Membrane-anchoring subunit of succinate dehydrogenase (SDH).
  
    0.758
YPO0192
Similar to several hypothetical proteins e.g. Escherichia coli hypothetical protein YheV SW:YHEV_ECOLI (P56622) (66 aa) fasta scores: E(): 8e-17, 60.3% id in 63 aa.
  
     0.690
nfuA
Conserved hypothetical protein; Involved in iron-sulfur cluster biogenesis. Binds a 4Fe-4S cluster, can transfer this cluster to apoproteins, and thereby intervenes in the maturation of Fe/S proteins. Could also act as a scaffold/chaperone for damaged Fe/S proteins.
  
     0.673
cybA
Similar to Escherichia coli succinate dehydrogenase cytochrome b556 subunit SdhC SW:DHSC_ECOLI (P10446) (129 aa) fasta scores: E(): 0, 77.2% id in 127 aa, and to Vibrio cholerae succinate dehydrogenase, cytochrome b556 subunit VC2091 TR:Q9KQA9 (EMBL:AE004283) (130 aa) fasta scores: E(): 0, 75.0% id in 124 aa.
  
    0.647
sdhE
Conserved hypothetical protein; An FAD assembly protein, which accelerates covalent attachment of the cofactor into other proteins. Plays an essential role in the assembly of succinate dehydrogenase (SDH, respiratory complex II), an enzyme complex that is a component of both the tricarboxylic acid cycle and the electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit SdhA of SDH and other flavinylated proteins as well.
  
     0.573
syd
Syd protein; Interacts with the SecY protein in vivo. May bind preferentially to an uncomplexed state of SecY, thus functioning either as a chelating agent for excess SecY in the cell or as a regulatory factor that negatively controls the translocase function. Belongs to the Syd family.
  
     0.539
zipA
Putative cell division protein; Essential cell division protein that stabilizes the FtsZ protofilaments by cross-linking them and that serves as a cytoplasmic membrane anchor for the Z ring. Also required for the recruitment to the septal ring of downstream cell division proteins.
  
     0.530
YPO2080
Conserved hypothetical protein; Similar to Escherichia coli protein YcgL SW:YCGL_ECOLI (P76003) (108 aa) fasta scores: E(): 2.9e-24,71.8% id in 85 aa, and to Vibrio cholerae hypothetical protein VC1957 vc1957 TR:Q9KQP1 (EMBL:AE004271) (102 aa) fasta scores: E(): 6.1e-19, 60.0% id in 90 aa.
  
    0.527
YPO0331
Hypothetical protein; No significant database hits.
      
 0.510
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.