STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
slyAMarR-family transcriptional regulatory protein; Transcription regulator that can specifically activate or repress expression of target genes; Belongs to the SlyA family. (143 aa)    
Predicted Functional Partners:
ymoA
Modulating protein YmoA (histone-like protein); Modulates the thermoregulation of VirF, and hence the yop regulon, as well as the expression of the enterotoxin gene yst. Involved in chromosome structure and DNA topology; probably by means of compaction of DNA in conjunction with H-NS; probably requires H-NS to bind DNA (By similarity); Belongs to the Hha/YmoA/Cnu family.
  
   
 0.716
nagE
Similar to Escherichia coli PTS system,N-acetylglucosamine-specific IIABC component NagE SW:PTAA_ECOLI (P09323) (648 aa) fasta scores: E(): 0, 52.6% id in 683 aa, and to Vibrio furnissii PTS permease for N-acetylglucosamine and glucose NagE TR:P96161 (EMBL:U65014) (496 aa) fasta scores: E(): 0, 69.9% id in 495 aa.
   
 
 0.708
phoP
Response regulator protein; Similar to the previously sequenced Yersinia pestis PhoP protein TR:P74992 (EMBL:Y08758) (223 aa) fasta scores: E(): 0, 100.0% id in 223 aa, to Yersinia pseudotuberculosis PhoP protein TR:P74991 (EMBL:X66587) (223 aa) fasta scores: E(): 0, 99.1% id in 223 aa, to Yersinia enterocolitica PhoP protein TR:O87919 (EMBL:AJ011832) (200 aa) fasta scores: E(): 0, 98.5% id in 200 aa, and to Escherichia coli transcriptional regulatory protein PhoP SW:PHOP_ECOLI (P23836) (223 aa) fasta scores: E(): 0, 81.1% id in 222 aa.
   
  
 0.679
YPO1737
Similar to Proteus vulgaris regulatory protein PqrA SW:PQRA_PROVU (Q52620) (122 aa) fasta scores: E(): 2.4e-17,47.6% id in 103 aa, and to Escherichia coli regulatory protein SoxS SW:SOXS_ECOLI (P22539) (106 aa) fasta scores: E(): 2.2e-15, 38.5% id in 104 aa.
  
  
 0.678
csrA
Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s).
   
  
 0.678
psaE
Putative regulatory protein; Required for expression of pH 6 antigen.
   
  
 0.657
hid
Integration host factor alpha-subunit; This protein is one of the two subunits of integration host factor, a specific DNA-binding protein that functions in genetic recombination as well as in transcriptional and translational control. Belongs to the bacterial histone-like protein family.
   
    0.636
glcA
Similar to Escherichia coli PTS system,glucose-specific IIBC component Ptsg or Glca or UmG SW:PTGB_ECOLI (P05053) (477 aa) fasta scores: E(): 0, 90.4% id in 477 aa, and to Salmonella typhimurium PTS system,glucose-specific IIBC component PtsG SW:PTGB_SALTY (P37439) (477 aa) fasta scores: E(): 0, 88.7% id in 477 aa.
     
 0.625
lacZ
Beta-galactosidase; Similar to Escherichia coli beta-galactosidase LacZ SW:BGAL_ECOLI (P00722) (1023 aa) fasta scores: E(): 0,62.5% id in 1046 aa, and to Enterobacter cloacae beta-galactosidase lacZ SW:BGAL_ENTCL (Q47077) (1028 aa) fasta scores: E(): 0, 60.4% id in 1046 aa; Belongs to the glycosyl hydrolase 2 family.
     
 0.605
bglY
DNA-binding protein Hns; Similar to Escherichia coli histone-like DNA-binding protein Hns SW:HNS_ECOLI (P08936) (136 aa) fasta scores: E(): 0, 84.3% id in 134 aa, and to Similar to Serratia marcescens DNA-binding protein Hns SW:HNS_SERMA (P18955) (134 aa) fasta scores: E(): 0, 92.5% id in 134 aa; Belongs to the histone-like protein H-NS family.
   
  
 0.603
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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