STRING protein interaction network
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
protein homology
Your Input:
Gene Fusion
slyAMarr-family transcriptional regulatory protein; Transcription regulator that can specifically activate or repress expression of target genes (143 aa)    
Predicted Functional Partners:
Response regulator protein; Similar to the previously sequenced Yersinia pestis PhoP protein TR:P74992 (EMBL:Y08758) (223 aa) fasta scores: E(): 0, 100.0% id in 223 aa, to Yersinia pseudotuberculosis PhoP protein TR:P74991 (EMBL:X66587) (223 aa) fasta scores: E(): 0, 99.1% id in 223 aa, to Yersinia enterocolitica PhoP protein TR:O87919 (EMBL:AJ011832) (200 aa) fasta scores: E(): 0, 98.5% id in 200 aa, and to Escherichia coli transcriptional regulatory protein PhoP SW:PHOP_ECOLI (P23836) (223 aa) fasta scores: E(): 0, 81.1% id in 222 aa
Ph 6 antigen precursor (antigen 4) (adhesin); Fibrillar structure, part of fimbriae, necessary for full virulence
Modulating protein ymoa (histone-like protein); Modulates the thermoregulation of VirF, and hence the yop regulon, as well as the expression of the enterotoxin gene yst. Involved in chromosome structure and DNA topology; probably by means of compaction of DNA in conjunction with H-NS; probably requires H-NS to bind DNA (By similarity)
Putative regulatory protein; Required for expression of pH 6 antigen
Similar to Escherichia coli transcriptional regulatory protein OmpR SW:OMPR_ECOLI (P03025) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa and to Yersinia enterocolitica OmpR TR:P74982 (EMBL:Y08950) (239 aa) fasta scores: E(): 0, 98.7% id in 239 aa
Similar to Yersinia enterocolitica attachment invasion locus protein precursor Ail SW:AIL_YEREN (P16454) (178 aa) fasta scores: E(): 3.3e-28, 47.8% id in 184 aa,and to Yersinia pseudotuberculosis attachment invasion locus protein precursor Ail SW:AIL_YERPS (Q56957) (182 aa) fasta scores: E(): 5.8e-26, 44.8% id in 183 aa. Similar to YPO2905, YPO2190 and YPO2506
Putative two-component response regulator; Similar to Salmonella typhimurium transcriptional activator SsrB TR:O54305 (EMBL:Z95891) (193 aa) fasta scores: E(): 0, 52.9% id in 189 aa, and to Pseudomonas aeruginosa response regulator GacA or Pa2586 TR:AAG05974 (EMBL:U27988) (214 aa) fasta scores: E(): 2.3e-22, 34.3% id in 207 aa
Carbon storage regulator; A key translational regulator that binds mRNA to regulate translation initiation and/or mRNA stability. Mediates global changes in gene expression, shifting from rapid growth to stress survival by linking envelope stress, the stringent response and the catabolite repression systems. Usually binds in the 5'-UTR; binding at or near the Shine-Dalgarno sequence prevents ribosome-binding, repressing translation, binding elsewhere in the 5'-UTR can activate translation and/or stabilize the mRNA. Its function is antagonized by small RNA(s)
Putative two-component response regulator; Similar to Streptococcus pneumoniae response regulator Rr02 TR:Q9S1K0 (EMBL:AJ006392) (234 aa) fasta scores: E(): 0, 41.5% id in 234 aa, and to to Bacillus subtilis alkaline phosphatase synthesis transcriptional regulatory protein PhoP SW:PHOP_BACSU (P13792) (240 aa) fasta scores: E(): 0, 43.7% id in 231 aa
Yersinia multiple regulator; RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs
Your Current Organism:
Yersinia pestis CO92
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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