Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
crrProbable glucose-specific IIA component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Salmonella typhimurium PTS system,glucose-specific IIA component Crr SW:PTGA_SALTY (P02908) (168 aa) fasta scores: E(): 0, 94.0% id in 168 aa, and to Escherichia coli PTS system, glucose-specific IIA component Crr SW:PTGA_ECOLI (P08837) (168 aa) fasta scores: E(): 0,92.9% id in 168 aa. (169 aa)    
Predicted Functional Partners:
YPO0405
Similar to e.g. Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsI,SW:PT1_ECOLI (P08839) (575 aa) fasta scores: E(): 0, 36.0% id in 583 aa, but has both N- and C-terminal extensions. Also similar to Escherichia coli phosphoenolpyruvate-protein phosphotransferase PtsA,SW:PT1A_ECOLI (P32670) (711 aa) fasta scores: E(): 0, 64.5% id in 726 aa and to Escherichia coli putative phosphoenolpyruvate-protein phosphotransferase YpdD,SW:YPDD_ECOLI (P77439) (831 aa) fasta scores: E(): 0, 41.5% id in 853 aa.
 0.999
glcA
Similar to Escherichia coli PTS system,glucose-specific IIBC component Ptsg or Glca or UmG SW:PTGB_ECOLI (P05053) (477 aa) fasta scores: E(): 0, 90.4% id in 477 aa, and to Salmonella typhimurium PTS system,glucose-specific IIBC component PtsG SW:PTGB_SALTY (P37439) (477 aa) fasta scores: E(): 0, 88.7% id in 477 aa.
 0.999
hpr
Probable phosphocarrier protein component of a phosphoenolpyruvate-dependent phosphotransferase system (PTS). Similar to Escherichia coli and Salmonella typhimurium phosphocarrier protein PtsH SW:PTHP_ECOLI (P07006) (85 aa) fasta scores: E(): 4.9e-30, 97.6% id in 85 aa, and to Klebsiella pneumoniae phosphocarrier protein PtsH SW:PTHP_KLEPN (P16481) (85 aa) fasta scores: E(): 8e-30, 96.5% id in 85 aa.
 
 0.999
ptsI
PTS sytem, enzyme I component; General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr).
 0.999
treB
Similar to Escherichia coli PTS system,trehalose-specific IIBC component TreB SW:PTTB_ECOLI (P36672) (473 aa) fasta scores: E(): 0, 80.5% id in 471 aa,and to Vibrio cholerae PTS system, trehalose-specific IIBC component Vc0910 TR:Q9KTJ2 (EMBL:AE004175) (478 aa) fasta scores: E(): 0, 70.0% id in 474 aa.
 0.999
nagE
Similar to Escherichia coli PTS system,N-acetylglucosamine-specific IIABC component NagE SW:PTAA_ECOLI (P09323) (648 aa) fasta scores: E(): 0, 52.6% id in 683 aa, and to Vibrio furnissii PTS permease for N-acetylglucosamine and glucose NagE TR:P96161 (EMBL:U65014) (496 aa) fasta scores: E(): 0, 69.9% id in 495 aa.
  
 0.986
nagA
Similar to Escherichia coli N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_ECOLI (P15300) (382 aa) fasta scores: E(): 0, 75.1% id in 381 aa, and to Vibrio cholerae N-acetylglucosamine-6-phosphate deacetylase NagA SW:NAGA_VIBCH (O32445) (378 aa) fasta scores: E(): 0, 64.1% id in 376 aa.
 
  
 0.932
YPO0166
Putative glycosyl hydrolase; Similar to Escherichia coli 6-phospho-beta-glucosidase CelF SW:CELF_ECOLI (P17411) (449 aa) fasta scores: E(): 0, 43.2% id in 440 aa and to Vibrio cholerae 6-phospho-beta-glucosidase VC1284 TR:Q9KSH2 (EMBL:AE004207) (440 aa) fasta scores: E(): 0, 55.9% id in 433 aa.
 
  
 0.930
pgi
Similar to Escherichia coli glucose-6-phosphate isomerase Pgi SW:G6PI_ECOLI (P11537) (549 aa) fasta scores: E(): 0, 87.2% id in 548 aa, and to Vibrio cholerae glucose-6-phosphate isomerase Vc0374 TR:Q9KUY4 (EMBL:AE004125) (550 aa) fasta scores: E(): 0, 76.5% id in 548 aa.
    
 0.920
murQ
Putative glucokinase protein; Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D- lactate. Together with AnmK, is also required for the utilization of anhydro-N-acetylmuramic acid (anhMurNAc) either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling; Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.
    
 0.916
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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