STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Cooccurrence
Coexpression
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[Homology]
Score
macB2Putative ABC transporter, ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides. (678 aa)    
Predicted Functional Partners:
YPO2999
Putative HlyD family secretion protein; Similar to Escherichia coli stress-induced multidrug export protein AcrA SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 7.3e-07, 27.3% id in 348 aa, and to Pseudomonas syringae putative membrane fusion protein MfpA TR:AAG22807 (EMBL:AF297012) (400 aa) fasta scores: E(): 0,40.3% id in 370 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.993
macA
Putative HlyD family secretion protein; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. Confers resistance against macrolides (By similarity).
 
 
 0.973
macB1
Putative ABC transporter ATP-binding protein; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 0.966
YPO3483
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein A precursor AcrA or MtcA or Lir SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 0, 49.4% id in 360 aa,and to Escherichia coli acriflavin resistance protein E precursor AcrE or EnvC SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 0, 50.1% id in 353 aa. Similar to YPO3132 (50.0% identity in 372 aa overlap); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.915
acrA
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein A precursor AcrA or MtcA or Lir SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 0, 73.2% id in 396 aa. Similar to YPO3483 (50.0% identity in 372 aa overlap); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 
 0.913
lolC
Similar to Escherichia coli lipoprotein releasing system transmembrane protein LolC SW:LOLC_ECOLI (P75956) (399 aa) fasta scores: E(): 0, 78.5% id in 400 aa, and to Vibrio cholerae hypothetical protein Vc1884 TR:Q9KQW4 (EMBL:AE004263) (406 aa) fasta scores: E(): 0, 53.2% id in 402 aa.
  
 0.910
lolE
Similar to Escherichia coli lipoprotein releasing system transmembrane protein LolE SW:LOLE_ECOLI (P75958) (413 aa) fasta scores: E(): 0, 79.6% id in 411 aa.
  
 0.910
YPO1945
Putative membrane protein; Previously sequenced as Yersinia pestis hypothetical protein TR:Q9ZC55 (EMBL:AL031866) (387 aa) fasta scores: E(): 0, 100.0% id in 387 aa. Similar to Campylobacter jejuni putative integral membrane protein Cj1662 TR:Q9PM15 (EMBL:AL139079) (372 aa) fasta scores: E(): 0, 32.5% id in 375 aa.
  
 0.910
YPO0420
Similar to Vibrio cholerae putative multidrug resistance protein Vc1675 TR:Q9KRG7 (EMBL:AE004245) (343 aa) fasta scores: E(): 1.2e-22, 30.919% id in 359 aa, and to Pseudomonas aeruginosa probable Rnd efflux membrane fusion protein precursor Pa4374 TR:Q9HW28 (EMBL:AE004853) (376 aa) fasta scores: E(): 2.1e-13, 28.086% id in 324 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.886
YPO1000
Putative drug efflux protein; Similar to Escherichia coli acriflavin resistance protein A AcrA SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 1.9e-31, 32.8% id in 348 aa, and to Pseudomonas aeruginosa multidrug efflux system protein MexE TR:P95421 (EMBL:X99514) (414 aa) fasta scores: E(): 2e-26,30.5% id in 370 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.886
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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