STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
acrBMultidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein B AcrB or AcrE SW:ACRB_ECOLI (P31224) (1049 aa) fasta scores: E(): 0, 84.1% id in 1047 aa, and to Pseudomonas aeruginosa multidrug resistance protein mMxB or Pa0426 SW:MEXB_PSEAE (P52002) (1046 aa) fasta scores: E(): 0, 68.3% id in 1033 aa. Similar to YPO3043 (66.5% identity in 1032 aa overlap) and to YPO3482 (57.8% identity in 1044 aa overlap). (1050 aa)    
Predicted Functional Partners:
acrA
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein A precursor AcrA or MtcA or Lir SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 0, 73.2% id in 396 aa. Similar to YPO3483 (50.0% identity in 372 aa overlap); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.994
ibeB
Similar to Escherichia coli probable outer membrane lipoprotein IbeB precursor SW:IBEB_ECOLI (P77211) (457 aa) fasta scores: E(): 0, 38.8% id in 464 aa, and to Pseudomonas aeruginosa outer membrane protein OprM precursor or OprK or Pa0427 TR:AAG03816 (EMBL:L23839) (485 aa) fasta scores: E(): 0, 48.0% id in 469 aa.
 0.981
YPO3483
Multidrug efflux protein; Similar to Escherichia coli acriflavin resistance protein A precursor AcrA or MtcA or Lir SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 0, 49.4% id in 360 aa,and to Escherichia coli acriflavin resistance protein E precursor AcrE or EnvC SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 0, 50.1% id in 353 aa. Similar to YPO3132 (50.0% identity in 372 aa overlap); Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 0.974
hasF
Similar to Serratia marcescens haemophore (HasA) ABC-transporter outer membrane component, HasF TR:Q54452 (EMBL:X98513) (500 aa) fasta scores: E(): 0, 76.7% id in 455 aa, and to Escherichia coli ABC-transporter outer membrane protein, TolC SW:TOLC_ECOLI (P02930) (495 aa) fasta scores: E(): 0, 73.2% id in 470 aa.
 
 0.947
YPO1000
Putative drug efflux protein; Similar to Escherichia coli acriflavin resistance protein A AcrA SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 1.9e-31, 32.8% id in 348 aa, and to Pseudomonas aeruginosa multidrug efflux system protein MexE TR:P95421 (EMBL:X99514) (414 aa) fasta scores: E(): 2e-26,30.5% id in 370 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.947
yegM
Putitive HlyD family secretion protein; Similar to Escherichia coli acriflavin resistance protein E AcrE SW:ACRE_ECOLI (P24180) (385 aa) fasta scores: E(): 1.2e-26, 31.3% id in 361 aa, and to Escherichia coli hypothetical protein YegM SW:YEGM_ECOLI (P76397) (415 aa) fasta scores: E(): 0, 64.5% id in 409 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.895
macA
Putative HlyD family secretion protein; Part of the tripartite efflux system MacAB-TolC. MacA stimulates the ATPase activity of MacB by promoting the closed ATP- bound state of MacB, increases the capacity of MacB to bind macrolides such as erythromycin, and provides a physical link between MacB and TolC. Confers resistance against macrolides (By similarity).
  
 0.839
YPO2999
Putative HlyD family secretion protein; Similar to Escherichia coli stress-induced multidrug export protein AcrA SW:ACRA_ECOLI (P31223) (397 aa) fasta scores: E(): 7.3e-07, 27.3% id in 348 aa, and to Pseudomonas syringae putative membrane fusion protein MfpA TR:AAG22807 (EMBL:AF297012) (400 aa) fasta scores: E(): 0,40.3% id in 370 aa; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  0.818
yajC
Putative membrane protein; The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions.
   
 
 0.784
YPO0617
Putative membrane protein; CyaE is necessary for transport of calmodulin-sensitive adenylate cyclase-hemolysin (cyclolysin). Belongs to the outer membrane factor (OMF) (TC 1.B.17) family.
 
 0.764
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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