Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
amtBSimilar to Escherichia coli probable ammonium transporter AmtB SW:AMTB_ECOLI (P37905) (428 aa) fasta scores: E(): 0, 79.0% id in 420 aa, and to Xylella fastidiosa ammonium transporter Xf1844 TR:Q9PCD7 (EMBL:AE004005) (492 aa) fasta scores: E(): 0, 60.0% id in 423 aa. (431 aa)    
Predicted Functional Partners:
glnB
Similar to Escherichia coli hypothetical protein YhfZ SW:YHFZ_ECOLI (P45552) (273 aa) fasta scores: E(): 0,52.0% id in 273 aa, and to Bacillus halodurans hypothetical protein BH0586 TR:Q9KF99 (EMBL:AP001509) (306 aa) fasta scores: E(): 1.9e-29, 34.9% id in 307 aa. Possible alternative translational start sites. Contains a frameshift after codon 189. Frame shift occurs at a poly A decamer. The sequence has been checked and is believed to be correct.
 0.999
glnK
Similar to Escherichia coli nitrogen regulatory protein P-II GlnK SW:GLNK_ECOLI (P38504) (112 aa) fasta scores: E(): 0, 94.6% id in 112 aa, and to Klebsiella pneumoniae PII-like nitrogen regulatory protein GlnK TR:Q9ZA65 (EMBL:AJ006531) (112 aa) fasta scores: E(): 0,95.5% id in 112 aa; Belongs to the P(II) protein family.
 0.999
glnR
Two component regulatory protein involved in nitrogen assimilation; Similar to Escherichia coli nitrogen regulation protein NtrB SW:NTRB_ECOLI (P06712) (349 aa) fasta scores: E(): 0, 86.5% id in 349 aa.
 
 
 0.920
aspB
Similar to Escherichia coli glutamate synthase [NADPH] large chain precursor GltB or AspB SW:GLTB_ECOLI (P09831) (1517 aa) fasta scores: E(): 0, 87.4% id in 1497 aa, and to Vibrio cholerae glutamate synthase, large subunit Vc2376 TR:Q9KPJ1 (EMBL:AE004308) (1487 aa) fasta scores: E(): 0, 73.7% id in 1488 aa.
 
  
 0.848
glnA
Glutamine synthetase; Highly similar to Escherichia coli glutamine synthetase GlnA SW:GLNA_ECOLI (P06711) (468 aa) fasta scores: E(): 0, 91.5% id in 468 aa.
  
  
 0.717
aspA
Similar to Escherichia coli aspartate ammonia-lyase AspA SW:ASPA_ECOLI (P04422) (478 aa) fasta scores: E(): 0,89.3% id in 478 aa.
   
  
 0.651
arcB
Similar to Escherichia coli aerobic respiration control sensor protein ArcB SW:ARCB_ECOLI (P22763) (776 aa) fasta scores: E(): 0, 75.9% id in 781 aa, and to Vibrio cholerae sensor histidine kinase FexB or VC2369 TR:Q9KPJ8 (EMBL:AE004307) (785 aa) fasta scores: E(): 0, 58.8% id in 779 aa.
  
 0.651
barA
Two-component regulatory protein; Similar to Escherichia coli sensor protein BarA SW:BARA_ECOLI (P26607) (918 aa) fasta scores: E(): 0, 61.6% id in 928 aa, and to Erwinia carotovora subsp. carotovora sensor/regulator protein RpfA TR:O08235 (EMBL:U62023) (929 aa) fasta scores: E(): 0, 59.7% id in 938 aa.
  
 0.629
acn
Aconitate hydratase 1; Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
  
  
 0.611
glnD
[protein-PII] uridylyltransferase; Modifies, by uridylylation and deuridylylation, the PII regulatory proteins (GlnB and homologs), in response to the nitrogen status of the cell that GlnD senses through the glutamine level. Under low glutamine levels, catalyzes the conversion of the PII proteins and UTP to PII-UMP and PPi, while under higher glutamine levels, GlnD hydrolyzes PII-UMP to PII and UMP (deuridylylation). Thus, controls uridylylation state and activity of the PII proteins, and plays an important role in the regulation of nitrogen assimilation and metabolism.
 
   
 0.589
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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