STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
purHPhosphoribosylaminoimidazolecarboxamide formyltransferase; Similar to Escherichia coli bifunctional purine biosynthesis protein PurH SW:PUR9_ECOLI (P15639) (529 aa) fasta scores: E(): 0, 87.1% id in 529 aa, and to Salmonella typhimurium bifunctional purine biosynthesis protein PurH SW:PUR9_SALTY (P26978) (508 aa) fasta scores: E(): 0, 86.8% id in 508 aa. (529 aa)    
Predicted Functional Partners:
purN
Putative phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.999
purI-2
Phosphoribosylformylglycinamidine synthase; Phosphoribosylformylglycinamidine synthase involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate.
  
 
 0.999
purB
Similar to Escherichia coli adenylosuccinate lyase PurB SW:PUR8_ECOLI (P25739) (456 aa) fasta scores: E(): 0,88.6% id in 456 aa, and to Vibrio cholerae adenylosuccinate lyase Vc1126 TR:Q9KSY0 (EMBL:AE004193) (456 aa) fasta scores: E(): 0, 78.5% id in 456 aa.
  
 0.997
purD
Similar to Escherichia coli phosphoribosylamine--glycine ligase PurD SW:PUR2_ECOLI (P15640) (429 aa) fasta scores: E(): 0, 80.8% id in 426 aa,and to Salmonella typhimurium phosphoribosylamine--glycine ligase PurD or Stmf1.31 SW:PUR2_SALTY (P26977) (429 aa) fasta scores: E(): 0, 79.6% id in 426 aa.
 
 0.997
adeK
Adenylosuccinate synthetase; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 0.996
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.993
purT
Phosphoribosylglycinamide formyltransferase; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate; Belongs to the PurK/PurT family.
   
 
 0.991
purC
Similar to Escherichia coli phosphoribosylaminoimidazole-succinocarboxamide synthase PurC SW:PUR7_ECOLI (P21155) (237 aa) fasta scores: E(): 0,86.9% id in 237 aa, and to Pseudomonas aeruginosa phosphoribosylaminoimidazole-succinocarboxamide synthase Purc or Pa1013 TR:AAG04402 (EMBL:AE004533) (236 aa) fasta scores: E(): 0, 72.5% id in 236 aa; Belongs to the SAICAR synthetase family.
 
 0.990
guaB
Inosine-5'-monophosphate dehydrogenase; Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Belongs to the IMPDH/GMPR family.
  
 
 0.989
ads
Putative FolD bifunctional protein; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.988
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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