Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ubiDConserved hypothetical protein; Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. (498 aa)    
Predicted Functional Partners:
ubiX
Probable 3-octaprenyl-4-hydroxybenzoate carboxy-lyase; Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN; Belongs to the UbiX/PAD1 family.
 
 
 0.995
b4040
4-hydroxybenzoate octaprenyltransferase; Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
  
 0.980
YPO3480
Similar to Escherichia coli hypothetical protein YhbV SW:YHBV_ECOLI (P45475) (298 aa) fasta scores: E(): 0,75.9% id in 290 aa, and to Vibrio cholerae hypothetical protein VC0651 TR:Q9KU72 (EMBL:AE004151) (321 aa) fasta scores: E(): 0, 66.7% id in 288 aa.
 
 
 0.931
YPO3479
Putative protease; Similar to Proteus mirabilis STM-protease A TR:Q9ZA85 (EMBL:AF088981) (334 aa) fasta scores: E(): 0,83.8% id in 334 aa, and to Escherichia coli putative protease precursor YhbU SW:YHBU_ECOLI (P45527) (331 aa) fasta scores: E(): 0, 88.5% id in 331 aa.
 
 
 0.929
visC
Putative monooxygenase; Similar to Escherichia coli hypothetical VisC protein (which is required for the biosynthesis of ubiquinone) SW:VISC_ECOLI (P25535) (400 aa) fasta scores: E(): 0, 71.4% id in 402 aa, and to Escherichia coli 2-octaprenyl-3-methyl-6-methoxy-1,4-benzoquinol hydroxylase UbiF SW:UBIF_ECOLI (P75728) (391 aa) fasta scores: E(): 0,38.2% id in 395 aa.
    
 0.912
YPO3477
Putative lipid carrier protein; Similar to Escherichia coli hypothetical 19.7 kDa protein in sohA-mtr intergenic region YhbT SW:YHBT_ECOLI (P45474) (174 aa) fasta scores: E(): 0, 71.9% id in 160 aa,and to Vibrio cholerae hypothetical protein Vc0654 TR:Q9KU69 (EMBL:AE004151) (175 aa) fasta scores: E(): 0,54.0% id in 161 aa.
    
 0.912
fadI
Similar to Escherichia coli NAD(P)H-flavin reductase Fre or FlrD or FadI or FsrC or UbiB SW:FRE_ECOLI (P23486) (232 aa) fasta scores: E(): 0, 77.6% id in 232 aa, and to Salmonella typhimurium LT2 UbiB protein TR:Q9L6L9 (EMBL:AF233324) (233 aa) fasta scores: E(): 0, 79.4% id in 233 aa.
  
    0.860
ubiH
Similar to Escherichia coli 2-octaprenyl-6-methoxyphenol hydroxylase UbiH SW:UBIH_ECOLI (P25534) (392 aa) fasta scores: E(): 0, 66.1% id in 392 aa,and to Vibrio cholerae putative 2-octaprenyl-6-methoxyphenol hydroxylase VC2475 TR:Q9KP98 (EMBL:AE004317) (402 aa) fasta scores: E(): 0, 50.0% id in 394 aa.
    
 0.747
ubiE
Ubiquinone/menaquinone biosynthesis methyltransferase; Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2) and the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3- methyl-6-methoxy-1,4-benzoquinol (DMQH2).
 
  
 0.718
ascD
Cdp-6-deoxy-delta-3,4-glucoseen reductase; Participates in the conversion of CDP-6-deoxy-D-glycero-L- threo-4-hexulose to 3,6-dideoxy-D-glycero-D-glycero-4-hexulose together with CDP-6-deoxy-D-glycero-L-threo-4-hexulose-3-dehydrase (E1) in two consecutive steps. The detailed mechanism of E3 is not yet resolved (By similarity).
  
  
 0.658
Your Current Organism:
Yersinia pestis
NCBI taxonomy Id: 214092
Other names: Y. pestis CO92, Yersinia pestis CO92, Yersinia pestis str. CO92, Yersinia pestis strain CO92
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