STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Q5K6Y0_CRYNJUncharacterized protein. (737 aa)    
Predicted Functional Partners:
Q5KEC3_CRYNJ
Cleavage and polyadenylation specificity factor subunit 5; Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The [...]
   
 0.981
Q5KIP3_CRYNJ
Cleavage and polyadenylation specificity factor subunit 2.
   
 
 0.974
RNA14
mRNA 3'-end-processing protein RNA14; Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.
   
 
 0.967
CFT1
Protein CFT1; RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation- dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity); Belongs to the CFT1 family.
   
 
 0.965
Q5KHE4_CRYNJ
Fip1 domain-containing protein.
   
 
 0.878
CLP1
mRNA cleavage and polyadenylation factor CLP1; Required for endonucleolytic cleavage during polyadenylation- dependent pre-mRNA 3'-end formation.
   
 0.871
Q5KNU1_CRYNJ
Poly(A) polymerase; Polymerase that creates the 3'-poly(A) tail of mRNA's.
   
 0.869
Q5KBC4_CRYNJ
FHA domain-containing protein.
   
 0.826
Q5KND1_CRYNJ
G-patch_2 domain-containing protein.
   
 0.801
Q5KPS3_CRYNJ
Cleavage/polyadenylation specificity factor, putative.
   
 0.792
Your Current Organism:
Cryptococcus neoformans
NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.