STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
DCN1Defective in cullin neddylation protein 1; May contribute to neddylation of cullin components of SCF- type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). (279 aa)    
Predicted Functional Partners:
Q5KAP0_CRYNJ
E2 ubiquitin-conjugating enzyme, putative; Belongs to the ubiquitin-conjugating enzyme family.
    
 0.978
Q5KM35_CRYNJ
Ubiquitin-protein ligase, putative.
    
 0.971
Q5KDB7_CRYNJ
Ubiquitin-protein ligase, putative; Belongs to the cullin family.
   
 0.919
Q5KK31_CRYNJ
Ribosomal chaperone, putative.
    
 0.902
Q5K745_CRYNJ
Ubiquitin-protein ligase, putative; Belongs to the cullin family.
   
 0.888
Q5K747_CRYNJ
Expressed protein; Belongs to the cullin family.
   
 0.888
Q5KDE6_CRYNJ
Ubiquitin-protein ligase, putative; Belongs to the cullin family.
    
 0.887
RRI1
COP9 signalosome complex subunit 5; Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes; Belongs to the peptidase M67A family. CSN5 subfamily.
    
 0.835
Q5KKS5_CRYNJ
NEDD8 activating enzyme, putative.
    
 0.833
Q5K9Q6_CRYNJ
TIP120-family protein TIP120B, putative.
   
 0.794
Your Current Organism:
Cryptococcus neoformans
NCBI taxonomy Id: 214684
Other names: C. neoformans var. neoformans JEC21, Cryptococcus neoformans JEC21, Cryptococcus neoformans var. neoformans JEC21, Cryptococcus neoformans var. neoformans serotype D JEC21, Cryptococcus neoformans var. neoformans strain JEC21, Filobasidiella neoformans var. neoformans strain JEC21
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