STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
PV06_10458DUF1767 domain-containing protein. (296 aa)    
Predicted Functional Partners:
PV06_09739
DNA topoisomerase; Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. Belongs to the type IA topoisomerase family.
    
 0.975
PV06_00471
Uncharacterized protein.
    
 0.971
PV06_02655
ERCC4 domain-containing protein.
    
 0.969
PV06_11139
Uncharacterized protein.
    
 0.967
PV06_06992
Uncharacterized protein.
    
 0.967
PV06_02217
ERCC4 domain-containing protein.
    
 0.965
PV06_01662
Uncharacterized protein.
    
 0.962
PV06_03743
Replication protein A subunit; As part of the replication protein A (RPA/RP-A), a single- stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.
    
 0.962
PV06_02790
ATP-dependent DNA helicase; Belongs to the helicase family. RecQ subfamily.
    
 0.944
PV06_02614
DNA repair protein RAD51 homolog; Required both for recombination and for the repair of DNA damage caused by X-rays; Belongs to the RecA family. RAD51 subfamily.
    
 0.880
Your Current Organism:
Exophiala oligosperma
NCBI taxonomy Id: 215243
Other names: CBS 265.49, CBS 725.88, E. oligosperma, Exophiala oligosperma Calendron ex de Hoog & Tintelnot, Exophiala sp. CBS 725.88
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.