LOC104928409 protein (Larimichthys crocea) - STRING interaction network

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second shell of interactors

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Known Interactions

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Predicted Interactions

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protein homology

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Score

LOC104928409

Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1. (479 aa)

Predicted Functional Partners:

pdpk1

0.959

LOC104923989

0.958

LOC104932638

0.958

kdr

0.950

hras

0.934

pten

0.927

LOC104918805

0.927

pgr

0.917

prkci

0.913

mtor

0.909

Your Current Organism:

Larimichthys crocea

NCBI taxonomy Id: 215358
Other names: L. crocea, Pseudosciaena amblyceps, Pseudosciaena crocea, Sciaena crocea, croceine croaker, large yellow croaker

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
LOC104918805	LOC104928409	ENSLCRP00005038492	ENSLCRP00005054685	Ras-related C3 botulinum toxin substrate 1.	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	0.927
LOC104918805	LOC104932638	ENSLCRP00005038492	ENSLCRP00005027321	Ras-related C3 botulinum toxin substrate 1.	GRB2-associated-binding protein 1 isoform X1.	0.408
LOC104918805	pdpk1	ENSLCRP00005038492	ENSLCRP00005028740	Ras-related C3 botulinum toxin substrate 1.	3-phosphoinositide-dependent protein kinase 1 isoform X2.	0.443
LOC104918805	prkci	ENSLCRP00005038492	ENSLCRP00005064795	Ras-related C3 botulinum toxin substrate 1.	Atypical protein kinase C iota type.	0.424
LOC104923989	LOC104928409	ENSLCRP00005019476	ENSLCRP00005054685	Insulin receptor substrate 1-B.	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	0.958
LOC104923989	LOC104932638	ENSLCRP00005019476	ENSLCRP00005027321	Insulin receptor substrate 1-B.	GRB2-associated-binding protein 1 isoform X1.	0.441
LOC104923989	mtor	ENSLCRP00005019476	ENSLCRP00005017043	Insulin receptor substrate 1-B.	Serine/threonine-protein kinase mTOR isoform X1.	0.928
LOC104928409	LOC104918805	ENSLCRP00005054685	ENSLCRP00005038492	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Ras-related C3 botulinum toxin substrate 1.	0.927
LOC104928409	LOC104923989	ENSLCRP00005054685	ENSLCRP00005019476	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Insulin receptor substrate 1-B.	0.958
LOC104928409	LOC104932638	ENSLCRP00005054685	ENSLCRP00005027321	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	GRB2-associated-binding protein 1 isoform X1.	0.958
LOC104928409	hras	ENSLCRP00005054685	ENSLCRP00005048215	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	GTPase HRas.	0.934
LOC104928409	kdr	ENSLCRP00005054685	ENSLCRP00005039650	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Vascular endothelial growth factor receptor 2 isoform X1.	0.950
LOC104928409	mtor	ENSLCRP00005054685	ENSLCRP00005017043	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Serine/threonine-protein kinase mTOR isoform X1.	0.909
LOC104928409	pdpk1	ENSLCRP00005054685	ENSLCRP00005028740	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	3-phosphoinositide-dependent protein kinase 1 isoform X2.	0.959
LOC104928409	pgr	ENSLCRP00005054685	ENSLCRP00005009845	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Progesterone receptor.	0.917
LOC104928409	prkci	ENSLCRP00005054685	ENSLCRP00005064795	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Atypical protein kinase C iota type.	0.913
LOC104928409	pten	ENSLCRP00005054685	ENSLCRP00005006569	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	Phosphatase and tensin homolog.	0.927
LOC104932638	LOC104918805	ENSLCRP00005027321	ENSLCRP00005038492	GRB2-associated-binding protein 1 isoform X1.	Ras-related C3 botulinum toxin substrate 1.	0.408
LOC104932638	LOC104923989	ENSLCRP00005027321	ENSLCRP00005019476	GRB2-associated-binding protein 1 isoform X1.	Insulin receptor substrate 1-B.	0.441
LOC104932638	LOC104928409	ENSLCRP00005027321	ENSLCRP00005054685	GRB2-associated-binding protein 1 isoform X1.	Phosphatidylinositol 3-kinase regulatory subunit gamma isoform X1.	0.958

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Network Stats

number of nodes:

11

number of edges:

55

average node degree:

10

avg. local clustering coefficient:

1

expected number of edges:

48

PPI enrichment p-value:

0.0411

your network has significantly more interactions
than expected (what does that mean?)

Functional enrichments in your networkNote: some enrichments may be expected here (why?)
disable highlight explain columns

Biological Process (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0006457

Protein folding

7 of 19

1.93

3.65

1.72e-09

GO:0009408

Response to heat

5 of 9

2.11

3.0

5.64e-07

GO:0042026

Protein refolding

2 of 3

2.18

0.82

0.0305

Molecular Function (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005515

Protein binding

6 of 29

1.68

2.35

1.11e-06

GO:0051082

Unfolded protein binding

4 of 10

1.96

2.27

1.77e-05

GO:0016887

ATP hydrolysis activity

4 of 41

1.35

1.16

0.00099

GO:0031072

Heat shock protein binding

2 of 4

2.06

1.16

0.0063

GO:0030554

Adenyl nucleotide binding

10 of 294

0.89

0.94

1.51e-06

(more ...)

Cellular Component (Gene Ontology)

GO-term

description

count in network

strength

signal

false discovery rate

GO:0005737

Cytoplasm

11 of 875

0.46

0.38

0.0010

Local Network Cluster (STRING)

cluster

description

count in network

strength

signal

false discovery rate

CL:398

Protein folding, and ATP-dependent peptidase activity

8 of 22

1.92

4.26

1.29e-11

CL:400

Stress response, and Protein folding chaperone

7 of 15

2.03

4.25

1.19e-10

CL:403

Stress response, and Protein folding chaperone

4 of 8

2.06

2.33

1.78e-05

Annotated Keywords (UniProt)

keyword

description

count in network

strength

signal

false discovery rate

KW-0346

Stress response

5 of 7

2.21

3.47

7.84e-08

KW-0143

Chaperone

5 of 13

1.95

2.88

4.19e-07

KW-0677

Repeat

3 of 10

1.84

1.45

0.0011

Protein Domains (Pfam)

domain

description

count in network

strength

signal

false discovery rate

PF02861

Clp amino terminal domain, pathogenicity island component

2 of 2

2.36

0.76

0.0400

Protein Domains and Features (InterPro)

domain

description

count in network

strength

signal

false discovery rate

IPR003959

ATPase, AAA-type, core

3 of 7

1.99

1.2

0.0049

IPR041546

ClpA/ClpB, AAA lid domain

2 of 2

2.36

0.79

0.0352

IPR036869

Chaperone J-domain superfamily

2 of 3

2.18

0.79

0.0352

IPR036628

Clp, N-terminal domain superfamily

2 of 2

2.36

0.79

0.0352

IPR028299

ClpA/B, conserved site 2

2 of 2

2.36

0.79

0.0352

(more ...)

Protein Domains (SMART)

domain

description

count in network

strength

signal

false discovery rate

SM01086

C-terminal, D2-small domain, of ClpB protein

2 of 4

2.06

0.87

0.0232

SM00271

DnaJ molecular chaperone homology domain

2 of 4

2.06

0.87

0.0232

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