STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hyaDProtein hydD; Derived by automated computational analysis using gene prediction method: Protein Homology. (182 aa)    
Predicted Functional Partners:
hydC
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.987
hyaB
Hydrogenase 2 large subunit; Involved in hydrogen uptake; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.986
KGL12613.1
Ni/Fe hydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.959
KGL13429.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: GeneMarkS+.
    
 
 0.903
KGL12609.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
     
 0.788
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
    
   0.603
ileS
isoleucyl-tRNA synthase; Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile). Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.
   
   0.587
hypC
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
  
 0.543
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.541
hypD
Hydrogenase formation protein HypD; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the HypD family.
 
   
 0.500
Your Current Organism:
Helicobacter muridarum
NCBI taxonomy Id: 216
Other names: ATCC 49282, CCUG 29262, CIP 104248, DSM 22221, H. muridarum, LMG 13646, LMG:13646, NCTC 12714, strain ST1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.