STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
hemCPorphobilinogen deaminase HemC; Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps. Belongs to the HMBS family. (290 aa)    
Predicted Functional Partners:
hemB
Delta-aminolevulinic acid dehydratase HemB; Belongs to the ALAD family.
 
 0.999
hemD
uroporphyrinogen-III synthase HemD.
 0.999
cobA
uroporphyrin-III C-methyltransferase CobA; Belongs to the precorrin methyltransferase family.
 
 0.993
hemA
glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
  
 0.990
hemL
Glutamate-1-semialdehyde-2,1-aminomutase HemL.
 
  
 0.947
BRM9_1907
Oxidoreductase GFO/IDH/MOCA family.
     
 0.927
glyA
Serine hydroxymethyltransferase GlyA; Catalyzes the reversible interconversion of serine and glycine with tetrahydromethanopterin (H4MPT) serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro- aldol mechanism; Belongs to the SHMT family.
     
 0.892
pyrE2
Orotate phosphoribosyltransferase PyrE2; Belongs to the purine/pyrimidine phosphoribosyltransferase family.
       0.865
purD
Phosphoribosylamine-glycine ligase PurD; Belongs to the GARS family.
  
  
 0.855
cysG
Siroheme synthase CysG.
 
 
 0.841
Your Current Organism:
Methanobacterium formicicum
NCBI taxonomy Id: 2162
Other names: ATCC 33274, JCM 10132, M. formicicum, Methanobacterium sp. BRM9, NBRC 100475, OCM 55, strain MF
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.