Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
hypCHydrogenase assembly chaperone HypC. (83 aa)    
Predicted Functional Partners:
hypD
Hydrogenase expression/formation protein HypD.
 
 
 0.995
hypE2
Hhydrogenase expression/formation protein HypE2.
 
 
 0.990
hypF
Hydrogenase maturation factor HypF.
 
 
 0.957
hypB
Hydrogenase accessory protein HypB.
 
  
 0.925
hypA
Hydrogenase nickel insertion protein HypA; Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase.
 
  
 0.917
BRM9_1807
CobW/HypB/UreG nucleotide-binding domain-containing protein.
  
  
 0.739
frhA
Coenzyme F420 hydrogenase alpha subunit FrhA; Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family.
 
 
 0.708
BRM9_2003
Dihydrolipoamide dehydrogenase-related protein.
       0.628
frhD
Coenzyme F420 hydrogenase delta subunit FrhD.
 
  
 0.601
tfb
Transcription initiation factor TFIIB Tfb; Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB).
  
   
 0.576
Your Current Organism:
Methanobacterium formicicum
NCBI taxonomy Id: 2162
Other names: ATCC 33274, JCM 10132, M. formicicum, Methanobacterium sp. BRM9, NBRC 100475, OCM 55, strain MF
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