Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
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[Homology]
Score
nnrECarbohydrate kinase; Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX; Belongs to the NnrE/AIBP family. (215 aa)    
Predicted Functional Partners:
nnrD
Carbohydrate kinase; Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S-and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.
  
 0.979
KJW12286.1
ADP-ribose pyrophosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.883
KJW11792.1
7,8-dihydro-8-oxoguanine-triphosphatase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.883
cshA
RNA helicase; DEAD-box RNA helicase possibly involved in RNA degradation. Unwinds dsRNA in both 5'- and 3'-directions, has RNA-dependent ATPase activity; Belongs to the DEAD box helicase family. CshA subfamily.
  
 0.794
cshB
DEAD/DEAH box helicase; Probable DEAD-box RNA helicase. May work in conjunction with the cold shock proteins to ensure proper initiation of transcription at low and optimal temperatures.
  
 0.794
KJW11695.1
Helicase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.794
KJW13775.1
Transcriptional regulator; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.682
KJW12756.1
Dihydropyrimidine dehydrogenase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
   0.677
KJW13296.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
   0.620
KJW13776.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.486
Your Current Organism:
Lactobacillus spicheri
NCBI taxonomy Id: 216463
Other names: DSM 15429, JCM 15956, L. spicheri, LMG 21871, LMG:21871, LTH 5753, Lactobacillus spicheri Meroth et al. 2004
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