close STRING v12.5 is now available!
The next version of STRING is ready for use in your analyses: updated networks across STRING • newly available directed regulatory networks • a new typed view showing functional, physical, and regulatory edges in one network • new clustering options and cluster-based layouts • … and much more!
Explore STRING v12.5 →
STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
dnaEDNA polymerase III DnaE; Catalyzes DNA-template-directed extension of the 3'-end of a DNA strand by one nucleotide at a time. Proposed to be responsible for the synthesis of the lagging strand. In the low GC gram positive bacteria this enzyme is less processive and more error prone than its counterpart in other bacteria; Derived by automated computational analysis using gene prediction method: Protein Homology. (1109 aa)    
Predicted Functional Partners:
KJW12630.1
DNA polymerase III subunit beta; Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP- independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of [...]
  
 
 0.998
KJW12244.1
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.998
dnaX
DNA polymerase III subunit gamma/tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
 
 0.993
KJW13078.1
DNA polymerase III subunit delta; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 0.993
KJW13144.1
DNA polymerase III subunit alpha; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.989
polC
DNA polymerase III PolC; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
    
0.948
dinG
DNA helicase; 3'-5' exonuclease.
 
 0.909
KJW11739.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
   
 0.907
KJW13611.1
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.885
KJW12842.1
Single-stranded DNA-binding protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
 
 0.885
Your Current Organism:
Lactobacillus spicheri
NCBI taxonomy Id: 216463
Other names: DSM 15429, JCM 15956, L. spicheri, LMG 21871, LMG:21871, LTH 5753, Lactobacillus spicheri Meroth et al. 2004
Server load: medium (48%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.