node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
KJW11930.1 | KJW12037.1 | VC81_11970 | VC81_10725 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.729 |
KJW11930.1 | fhs | VC81_11970 | VC81_02345 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.662 |
KJW11930.1 | glyA | VC81_11970 | VC81_11800 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.691 |
KJW11930.1 | thyA | VC81_11970 | VC81_09415 | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.948 |
KJW12036.1 | KJW12037.1 | VC81_10720 | VC81_10725 | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.586 |
KJW12037.1 | KJW11930.1 | VC81_10725 | VC81_11970 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Folylpolyglutamate synthase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the folylpolyglutamate synthase family. | 0.729 |
KJW12037.1 | KJW12036.1 | VC81_10725 | VC81_10720 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.586 |
KJW12037.1 | KJW12245.1 | VC81_10725 | VC81_10160 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.532 |
KJW12037.1 | KJW13169.1 | VC81_10725 | VC81_04705 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.514 |
KJW12037.1 | fhs | VC81_10725 | VC81_02345 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Formate--tetrahydrofolate ligase; Derived by automated computational analysis using gene prediction method: Protein Homology; Belongs to the formate--tetrahydrofolate ligase family. | 0.517 |
KJW12037.1 | fmt | VC81_10725 | VC81_03195 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.510 |
KJW12037.1 | glyA | VC81_10725 | VC81_11800 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.525 |
KJW12037.1 | tdk | VC81_10725 | VC81_11780 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.551 |
KJW12037.1 | thyA | VC81_10725 | VC81_09415 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.856 |
KJW12037.1 | tmk | VC81_10725 | VC81_04885 | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.513 |
KJW12245.1 | KJW12037.1 | VC81_10160 | VC81_10725 | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Dihydrofolate reductase; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.532 |
KJW12245.1 | KJW13169.1 | VC81_10160 | VC81_04705 | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | dUTP diphosphatase; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. | 0.962 |
KJW12245.1 | tdk | VC81_10160 | VC81_11780 | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidine kinase; Catalyzes the formation of thymidine 5'-phosphate from thymidine; Derived by automated computational analysis using gene prediction method: Protein Homology. | 0.954 |
KJW12245.1 | thyA | VC81_10160 | VC81_09415 | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.956 |
KJW12245.1 | tmk | VC81_10160 | VC81_04885 | Competence protein ComE; Derived by automated computational analysis using gene prediction method: Protein Homology. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.952 |