node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_0249 | mtn | MMAR_0249 | MMAR_0251 | Transcriptional regulatory protein (possibly TetR-family); Possibly involved in transcriptional mechanism. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.567 |
MMAR_3921 | mtn | MMAR_3921 | MMAR_0251 | Conserved hypothetical phage DNA methylase; Function unknown; possible role in phage DNA restriction modification system. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.904 |
MMAR_3921 | sahH | MMAR_3921 | MMAR_1295 | Conserved hypothetical phage DNA methylase; Function unknown; possible role in phage DNA restriction modification system. | Adenosylhomocysteinase SahH; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.911 |
bioB | fas | MMAR_2387 | MMAR_3962 | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | 0.527 |
bioB | mtn | MMAR_2387 | MMAR_0251 | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.783 |
fas | bioB | MMAR_3962 | MMAR_2387 | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.527 |
fas | gltB | MMAR_3962 | MMAR_5413 | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | 0.466 |
fas | guaA | MMAR_3962 | MMAR_1148 | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | 0.615 |
fas | mtn | MMAR_3962 | MMAR_0251 | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.536 |
fas | sahH | MMAR_3962 | MMAR_1295 | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | Adenosylhomocysteinase SahH; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.438 |
gltB | fas | MMAR_5413 | MMAR_3962 | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | 0.466 |
gltB | guaA | MMAR_5413 | MMAR_1148 | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | 0.923 |
gltB | hisA | MMAR_5413 | MMAR_2399 | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.646 |
gltB | mtn | MMAR_5413 | MMAR_0251 | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.548 |
guaA | fas | MMAR_1148 | MMAR_3962 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. | 0.615 |
guaA | gltB | MMAR_1148 | MMAR_5413 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | Ferredoxin-dependent glutamate synthase [NADPH] (large subunit) GltB; Probably involved in glutamate biosynthesis [catalytic activity: 2 L-glutamate + NADP(+) = L-glutamine + 2-oxoglutarate + NADPH]. | 0.923 |
guaA | hisA | MMAR_1148 | MMAR_2399 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase HisA; Involved in both the histidine and tryptophan biosynthetic pathways; Belongs to the HisA/HisF family. | 0.806 |
guaA | mtn | MMAR_1148 | MMAR_0251 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | Bifunctional Mta/Sah nucleosidase Mtn; Catalyzes the irreversible cleavage of the glycosidic bond in both 5'-methylthioadenosine (MTA) and S-adenosylhomocysteine (SAH/AdoHcy) to adenine and the corresponding thioribose, 5'- methylthioribose and S-ribosylhomocysteine, respectively. Belongs to the PNP/UDP phosphorylase family. MtnN subfamily. | 0.576 |
guaA | pnp | MMAR_1148 | MMAR_0881 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | 5'-methylthioadenosine phosphorylase, Pnp; Catalyzes the reversible phosphorylation of S-methyl-5'- thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates; Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily. | 0.582 |
guaA | sahH | MMAR_1148 | MMAR_1295 | GMP synthase, GuaA; Catalyzes the synthesis of GMP from XMP. | Adenosylhomocysteinase SahH; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. | 0.430 |