Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
oxcAoxalyl-CoA decarboxylase OxcA; Involved in catabolism of oxalic acid [catalytic activity: oxalyl-CoA = formyl-CoA + CO2]; Belongs to the TPP enzyme family. (587 aa)    
Predicted Functional Partners:
ilvN
Acetolactate synthase (small subunit) IlvN; Involved in valine and isoleucine biosynthesis (at the first step) [catalytic activity: 2-acetolactate + CO(2) = 2-pyruvate].
 
 
 0.889
fadD7
fatty-acid-CoA ligase FadD7; Function unknown, but involved in lipid degradation.
  
 0.863
ilvC
Ketol-acid reductoisomerase IlvC; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
 
  
 0.701
ilvD
Dihydroxy-acid dehydratase IlvD; Involved in valine and isoleucine biosynthesis (at the fourth step) [catalytic activity: 2,3-dihydroxy-3- methylbutanoate = 3-methyl-2- oxobutanoate + H(2)O]; Belongs to the IlvD/Edd family.
 
 
 0.669
leuB
3-isopropylmalate dehydrogenase LeuB; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.
 
 
 0.640
MMAR_3408
Pyruvate ferredoxin/flavodoxin oxidoreductase family protein; Function unknown; probably involved in cellular metabolism.
  
  
 0.629
MMAR_1493
Conserved protein.
 
 
 0.624
MMAR_2060
Catalase; Has an organic peroxide-dependent peroxidase activity. Belongs to the catalase family.
  
 0.611
katE
Catalase KatE; Protects against oxidative stress. converts hydrogen peroxide to water and molecular oxygen.
  
 0.611
leuA
2-isopropylmalate synthase LeuA; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.
  
 
 0.609
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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