STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
pknK_3Serine/threonine-protein kinase transcriptional regulatory protein PknK_3; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. (1016 aa)    
Predicted Functional Partners:
pstP
Serine/threonine phosphatase PstP; Involved in regulation (using dephosphorylation of a specific phosphorylated substrate).
 
 
 0.853
embR_1
Transcriptional regulatory protein EmbR_1; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
 
 0.702
embR
Transcriptional regulatory protein EmbR; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
 
 0.627
embR_2
Transcriptional regulatory protein EmbR_2; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
 
 0.617
rpoB
DNA-directed RNA polymerase, beta subunit, RpoB; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.
   
 
 0.615
MMAR_2704
Conserved protein; Function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine.
 
 
 
 0.555
pknK_2
Serine/threonine-protein kinase transcriptional regulatory protein PknK_2; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
 
   
0.542
MMAR_0738
Two-component sensor and regulator.
  
 
 0.542
MMAR_0021
Conserved hypothetical membrane protein.
 
 
 
 0.493
MMAR_5186
Sensor-component of a two-component regulator.
  
 
 0.482
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
Server load: low (24%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.