Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
menCMuconate cycloisomerase, MenC; Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1- carboxylate (SHCHC) to 2-succinylbenzoate (OSB). (327 aa)    
Predicted Functional Partners:
menE
O-succinylbenzoic acid-CoA ligase, MenE; Involved in menaquinone biosynthesis. O- succinylbenzoic acid (OSB) to O-succinylbenzoyl-CoA (OSB- CoA) [catalytic activity: ATP + O-succinylbenzoate + CoA = AMP + diphosphate + O-succinylbenzoyl-CoA].
 
 
  0.952
menD
Bifunctional 2-succinyl-6-hydroxy-2,4- cyclohexadiene-1-carboxylate synthase, MenD; Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2- succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).
 
   
 0.947
menB
Naphthoate synthase, MenB; Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2- naphthoyl-CoA (DHNA-CoA); Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.
 
   
 0.932
MMAR_0898
Conserved hypothetical protein; Has significant domain identity to predicted metal- dependent hydrolases.
 
     0.883
bpoC
Bromoperoxidase BpoC; Non-haem peroxidase.
     
 0.861
fadD8
fatty-acid-CoA synthase, FadD8; Function unknown role in lipid metabolism.
  
    0.751
hmp
Flavodoxin reductase Hmp; May play a role in protection from oxidative (nitric oxide) and nitrosative stress. may also be involved in anaerobic metabolism. could have nitric oxide dioxygenase activity.
  
  
 0.727
pimB
Mannosyltransferase, PimB; Involved in lipoarabinomannan (lam) biosynthesis.
       0.696
rocD
Ornithine aminotransferase RocD1 and RocD2; Involved in arginine metabolism [catalytic activity: L-ornithine + a 2-OXO acid = L-glutamate 5- semialdehyde + an L-amino acid]; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.
     
 0.683
MMAR_1721
Conserved hypothetical protein.
      
 0.675
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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