node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_4230 | gyrB | MMAR_4230 | MMAR_0005 | Conserved hypothetical protein. | DNA gyrase (subunit B) GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.803 |
MMAR_4230 | mrsA | MMAR_4230 | MMAR_1108 | Conserved hypothetical protein. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.826 |
MMAR_4230 | mshC | MMAR_4230 | MMAR_3110 | Conserved hypothetical protein. | cysteinyl-tRNA synthetase, MshC; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.800 |
MMAR_4230 | rpoZ | MMAR_4230 | MMAR_2203 | Conserved hypothetical protein. | DNA-directed RNA polymerase (omega chain) RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.808 |
glmS | glmU | MMAR_1114 | MMAR_4467 | Glucosamine-fructose-6-phosphate aminotransferase, GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | 0.971 |
glmS | mrsA | MMAR_1114 | MMAR_1108 | Glucosamine-fructose-6-phosphate aminotransferase, GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.995 |
glmS | nagA | MMAR_1114 | MMAR_1190 | Glucosamine-fructose-6-phosphate aminotransferase, GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | N-acetylglucosamine-6-phosphate deacetylase NagA; Involved in N-acetyl glucosamine utilization pathway [catalytic activity: N-acetyl-D-glucosamine 6- phosphate + H(2)O = D-glucosamine 6-phosphate + acetate]. | 0.978 |
glmU | glmS | MMAR_4467 | MMAR_1114 | UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | Glucosamine-fructose-6-phosphate aminotransferase, GlmS; Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source. | 0.971 |
glmU | mrsA | MMAR_4467 | MMAR_1108 | UDP-N-acetylglucosamine pyrophosphorylase GlmU; Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C- terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N- acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5- triphosphate), a reaction catalyzed by the N-terminal domain. In the C-terminal section; belongs to the transferase hexapeptide repeat family. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.993 |
gyrB | MMAR_4230 | MMAR_0005 | MMAR_4230 | DNA gyrase (subunit B) GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Conserved hypothetical protein. | 0.803 |
gyrB | mrsA | MMAR_0005 | MMAR_1108 | DNA gyrase (subunit B) GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.765 |
gyrB | mshC | MMAR_0005 | MMAR_3110 | DNA gyrase (subunit B) GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | cysteinyl-tRNA synthetase, MshC; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.532 |
gyrB | rpoZ | MMAR_0005 | MMAR_2203 | DNA gyrase (subunit B) GyrB; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | DNA-directed RNA polymerase (omega chain) RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.760 |
lsr2 | mmpL11 | MMAR_5101 | MMAR_0442 | Iron-regulated Lsr2 protein precursor; Dominant T-cell antigen and may stimulate lymphocyte proliferation. | Conserved transmembrane transport protein MmpL11; Function unknown. thought to be involved in fatty acid transport. | 0.508 |
lsr2 | mrsA | MMAR_5101 | MMAR_1108 | Iron-regulated Lsr2 protein precursor; Dominant T-cell antigen and may stimulate lymphocyte proliferation. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.838 |
lsr2 | mshC | MMAR_5101 | MMAR_3110 | Iron-regulated Lsr2 protein precursor; Dominant T-cell antigen and may stimulate lymphocyte proliferation. | cysteinyl-tRNA synthetase, MshC; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.814 |
lsr2 | rpoZ | MMAR_5101 | MMAR_2203 | Iron-regulated Lsr2 protein precursor; Dominant T-cell antigen and may stimulate lymphocyte proliferation. | DNA-directed RNA polymerase (omega chain) RpoZ; Promotes RNA polymerase assembly. Latches the N- and C- terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits. | 0.873 |
mmpL11 | lsr2 | MMAR_0442 | MMAR_5101 | Conserved transmembrane transport protein MmpL11; Function unknown. thought to be involved in fatty acid transport. | Iron-regulated Lsr2 protein precursor; Dominant T-cell antigen and may stimulate lymphocyte proliferation. | 0.508 |
mmpL11 | mrsA | MMAR_0442 | MMAR_1108 | Conserved transmembrane transport protein MmpL11; Function unknown. thought to be involved in fatty acid transport. | Phosphomannomutase, MrsA; Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate; Belongs to the phosphohexose mutase family. | 0.796 |
mmpL11 | mshC | MMAR_0442 | MMAR_3110 | Conserved transmembrane transport protein MmpL11; Function unknown. thought to be involved in fatty acid transport. | cysteinyl-tRNA synthetase, MshC; Catalyzes the ATP-dependent condensation of GlcN-Ins and L- cysteine to form L-Cys-GlcN-Ins; Belongs to the class-I aminoacyl-tRNA synthetase family. MshC subfamily. | 0.585 |