STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
neiEndonuclease VIII Nei; Involved in damage reversal. DNA N-glycosylase with an ap lyase activity. required for the repair of oxidative DNA damage (oxidized pyrimidines). (254 aa)    
Predicted Functional Partners:
lhr
ATP-dependent helicase Lhr; Function unknown but has both ATPase and helicase activities.
 
  
 0.982
MMAR_3812
formamidopyrimidine-DNA glycosylase; Hydrolyses DNA (this enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents); Belongs to the FPG family.
  
  
 
0.927
rnc
Ribonuclease III Rnc; Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.
     
 0.883
recA
Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
  
 0.846
MMAR_1239
Transcriptional regulatory protein (probably TetR-family); Involved in transcriptional mechanism.
       0.808
MMAR_3235
Conserved hypothetical protein; Function unknown but contains domain identity with the nuclease subunit of UvrC excinucleases.
  
  
 0.753
pcd
Piperideine-6-carboxilic acid dehydrogenase Pcd; Involved in L-alpha-aminoadipic acid (L-AAA) biosynthesis (in the second step; the first step is promoted by Lat enzyme; Belongs to the aldehyde dehydrogenase family.
       0.697
MMAR_4559
formamidopyrimidine-DNA glycosylase; This enzyme may play a significant role in processes leading to recovery from mutagenesis and/or cell death by alkylating agents [catalytic activity: hydrolysis of DNA containing ring-opened N7-methylguanine residues, releasing 2,6-diamino-4-hydroxy-5-(N- methyl)formamidopyrimide]; Belongs to the FPG family.
  
   
0.676
polA
DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.646
mutY
Adenine glycosylase MutY; Involved in base excision repair. removes adenine mispaired with 8-OXOG. may repair a.G and a.C mismatches by adenine excision.
  
  
 0.556
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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