Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
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Co-occurrence
Co-expression
Experiments
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[Homology]
Score
sirRTranscriptional repressor SirR; Involved in transcriptional mechanism. (230 aa)    
Predicted Functional Partners:
MMAR_1626
Transcriptional regulator.
   
    0.758
MMAR_4466
Transcriptional regulatory protein (probably TetR-family); Involved in transcriptional mechanism.
  
  
 0.745
sigJ
The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released.
  
    0.744
ribF
Bifunctional fad synthetase/riboflavin biosynthesis protein RibF; Involved in fad biosynthesis [catalytic activity 1: ATP + riboflavin = ADP + FMN] [catalytic activity 2: ATP + FMN = diphosphate + fad]; Belongs to the ribF family.
       0.730
MMAR_0533
Transcriptional regulatory protein; Could be involved in transcriptional mechanism.
  
  
 0.727
cobB-3
Transcriptional regulatory protein; Involved in transcriptional mechanism; Belongs to the sirtuin family. Class III subfamily.
  
    0.720
MMAR_1279
Causes DNA methylation.
   
    0.717
embR
Transcriptional regulatory protein EmbR; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB.
   
  
 0.707
MMAR_3210
Conserved regulatory protein.
   
    0.700
MMAR_1019
Involved in transcriptional mechanism.
  
  
 0.698
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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