STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sthASoluble pyridine nucleotide transhydrogenase SthA; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [catalytic activity: NADPH + NAD(+) = NADP(+) + NADH]. (471 aa)    
Predicted Functional Partners:
kgd
Alpha-ketoglutarate decarboxylase Kgd; This enzyme is the key component of an alternative TCA cycle, converting a-ketoglutarate to succinic semialdehyde and then via GabD1/GabD2 to succinate.
  
 0.999
pntAb
NAD(P) transhydrogenase (subunit alpha) PntAb; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.945
pntB
NAD(P) transhydrogenase (subunit beta) PntB; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
   
 
 0.937
sucB
Pyruvate dehydrogenase (E2 component) SucB; Involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2.
 0.932
pntAa
NAD(P) transhydrogenase (subunit alpha) PntAa; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.926
nadE
Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.925
cobB-3
Transcriptional regulatory protein; Involved in transcriptional mechanism; Belongs to the sirtuin family. Class III subfamily.
  
 0.919
ppnK
Inorganic polyphosphate/ATP-NAD kinase, PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.907
nadD
Nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
   
 
 0.905
nudC
NADH pyrophosphatase NudC; Involved in nicotinate and nicotinamide metabolism. generates AMP and NMN from NAD(+) and H(2)O. acting on acid anhydrides, in phosphorus-containing anhydrides. also acts on NADP+, 3-acetylpyridine and the thionicotinamide analogues of NAD+ and NADP+ [CATA.
     
 0.904
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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