STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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Co-occurrence
Co-expression
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[Homology]
Score
sthASoluble pyridine nucleotide transhydrogenase SthA; Conversion of NADPH, generated by peripheral catabolic pathways, to NADH, which can enter the respiratory chain for energy generation [catalytic activity: NADPH + NAD(+) = NADP(+) + NADH]. (471 aa)    
Predicted Functional Partners:
kgd
Alpha-ketoglutarate decarboxylase Kgd; This enzyme is the key component of an alternative TCA cycle, converting a-ketoglutarate to succinic semialdehyde and then via GabD1/GabD2 to succinate.
  
 0.993
pntB
NAD(P) transhydrogenase (subunit beta) PntB; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane; Belongs to the PNT beta subunit family.
     
 0.940
cobB-3
Transcriptional regulatory protein; Involved in transcriptional mechanism; Belongs to the sirtuin family. Class III subfamily.
   
 0.916
pntAb
NAD(P) transhydrogenase (subunit alpha) PntAb; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.915
pntAa
NAD(P) transhydrogenase (subunit alpha) PntAa; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.914
nadE
Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.912
MMAR_1560
Conserved hypothetical protein; Function unknown but contains tetrapyrrole methyltransferase domain and MazG-like (predicted pyrophosphatase) domain.
    
 0.907
sucB
Pyruvate dehydrogenase (E2 component) SucB; Involved in tricarboxylic acid cycle; converts 2- oxoglutarate to succinyl-CoA and CO2.
 0.907
MMAR_4464
Conserved hypothetical protein.
    
 0.907
ppnK
Inorganic polyphosphate/ATP-NAD kinase, PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.
    
 0.905
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.