STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ideRTranscriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. (230 aa)    
Predicted Functional Partners:
sigB
RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released.
  
  
 0.891
zur
Zinc uptake regulation protein Zur; Acts as a global negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes; Belongs to the Fur family.
  
  
 0.785
bfrB
Bacterioferritin BfrB; Involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited.
     
 0.713
bfrA
Bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family.
      
 0.697
hemL
Glutamate-1-semialdehyde 2,1-aminomutase, HemL; Involved in porphyrin biosynthesis by the C5 pathway (at the second step) [catalytic activity: (S)-4- amino-5-oxopentanoate = 5-aminolevulinate].
     
 0.678
furA
Ferric uptake regulation protein FurA; Acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; Belongs to the Fur family.
  
  
 0.662
hemA
glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).
   
  
 0.641
argR
Arginine repressor ArgR; Regulates arginine biosynthesis genes.
     
 0.614
pepD
Serine protease PepD; Function unknown, possibly hydrolyzes peptides and/or proteins (seems to cleave preferentially after serine residues).
  
    0.614
MMAR_1971
Conserved 35 kDa alanine rich protein; Function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription.
   
  
 0.594
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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