| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| MMAR_1971 | ideR | MMAR_1971 | MMAR_2002 | Conserved 35 kDa alanine rich protein; Function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.594 |
| MMAR_1971 | sigB | MMAR_1971 | MMAR_2003 | Conserved 35 kDa alanine rich protein; Function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription. | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.780 |
| argR | ideR | MMAR_2467 | MMAR_2002 | Arginine repressor ArgR; Regulates arginine biosynthesis genes. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.614 |
| bfrA | bfrB | MMAR_2761 | MMAR_5393 | Bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | Bacterioferritin BfrB; Involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited. | 0.988 |
| bfrA | ideR | MMAR_2761 | MMAR_2002 | Bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.697 |
| bfrB | bfrA | MMAR_5393 | MMAR_2761 | Bacterioferritin BfrB; Involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited. | Bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | 0.988 |
| bfrB | ideR | MMAR_5393 | MMAR_2002 | Bacterioferritin BfrB; Involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.713 |
| furA | ideR | MMAR_2915 | MMAR_2002 | Ferric uptake regulation protein FurA; Acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; Belongs to the Fur family. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.662 |
| furA | sigB | MMAR_2915 | MMAR_2003 | Ferric uptake regulation protein FurA; Acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; Belongs to the Fur family. | RNA polymerase sigma factor SigB; Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. | 0.655 |
| furA | zur | MMAR_2915 | MMAR_3669 | Ferric uptake regulation protein FurA; Acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; Belongs to the Fur family. | Zinc uptake regulation protein Zur; Acts as a global negative controlling element, employing Zn(2+) as a cofactor to bind the operator of the repressed genes; Belongs to the Fur family. | 0.883 |
| hemA | hemL | MMAR_0842 | MMAR_0870 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Glutamate-1-semialdehyde 2,1-aminomutase, HemL; Involved in porphyrin biosynthesis by the C5 pathway (at the second step) [catalytic activity: (S)-4- amino-5-oxopentanoate = 5-aminolevulinate]. | 0.997 |
| hemA | ideR | MMAR_0842 | MMAR_2002 | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.641 |
| hemL | hemA | MMAR_0870 | MMAR_0842 | Glutamate-1-semialdehyde 2,1-aminomutase, HemL; Involved in porphyrin biosynthesis by the C5 pathway (at the second step) [catalytic activity: (S)-4- amino-5-oxopentanoate = 5-aminolevulinate]. | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.997 |
| hemL | ideR | MMAR_0870 | MMAR_2002 | Glutamate-1-semialdehyde 2,1-aminomutase, HemL; Involved in porphyrin biosynthesis by the C5 pathway (at the second step) [catalytic activity: (S)-4- amino-5-oxopentanoate = 5-aminolevulinate]. | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | 0.678 |
| ideR | MMAR_1971 | MMAR_2002 | MMAR_1971 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | Conserved 35 kDa alanine rich protein; Function unknown but domain identity to COG1842, PspA, phage shock protein a (IM30), suppresses sigma54- dependent transcription. | 0.594 |
| ideR | argR | MMAR_2002 | MMAR_2467 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | Arginine repressor ArgR; Regulates arginine biosynthesis genes. | 0.614 |
| ideR | bfrA | MMAR_2002 | MMAR_2761 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | Bacterioferritin BfrA; Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex; Belongs to the bacterioferritin family. | 0.697 |
| ideR | bfrB | MMAR_2002 | MMAR_5393 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | Bacterioferritin BfrB; Involved in iron storage; ferritin is an intracellular molecule that stores iron in a soluble, nontoxic, readily available form. the functional molecule, which is composed of 24 chains, is roughly spherical and contains a central cavity in which the polymeric ferric iron core is deposited. | 0.713 |
| ideR | furA | MMAR_2002 | MMAR_2915 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | Ferric uptake regulation protein FurA; Acts as a global negative controlling element, employing fe(2+) as a cofactor to bind the operator of the repressed genes. seems to regulate transcription of KatG gene; Belongs to the Fur family. | 0.662 |
| ideR | hemA | MMAR_2002 | MMAR_0842 | Transcriptional regulatory protein (repressor and activator), iron-binding repressor of siderophore biosynthesis and iron uptake. seems to regulate a variety of genes encoding a variety of proteins E.G. transporters, proteins involved in siderophore synthesis and iron storage, members of the PE/PPE family, enzymes involved in lipid metabolism, transcriptional regulatory proteins, etc. also activator of BfrA gene. | glutamyl-tRNA reductase HemA; Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA). | 0.641 |