node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MMAR_2016 | MMAR_2018 | MMAR_2016 | MMAR_2018 | Conserved hypothetical membrane protein. | Conserved hypothetical protein. | 0.843 |
MMAR_2016 | dut | MMAR_2016 | MMAR_2017 | Conserved hypothetical membrane protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.780 |
MMAR_2018 | MMAR_2016 | MMAR_2018 | MMAR_2016 | Conserved hypothetical protein. | Conserved hypothetical membrane protein. | 0.843 |
MMAR_2018 | dut | MMAR_2018 | MMAR_2017 | Conserved hypothetical protein. | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.874 |
MMAR_3773 | dut | MMAR_3773 | MMAR_2017 | Conserved protein; Function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain. | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.778 |
MMAR_3773 | fgd1 | MMAR_3773 | MMAR_0709 | Conserved protein; Function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain. | F420-dependent glucose-6-phosphate dehydrogenase Fgd1; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.679 |
MMAR_3773 | ndkA | MMAR_3773 | MMAR_3769 | Conserved protein; Function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain. | Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.458 |
dcd | dut | MMAR_0600 | MMAR_2017 | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | 0.933 |
dcd | ndkA | MMAR_0600 | MMAR_3769 | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.928 |
dcd | thyA | MMAR_0600 | MMAR_1956 | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.491 |
dcd | thyX | MMAR_0600 | MMAR_1961 | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate synthase ThyX; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant. | 0.459 |
dcd | tmk | MMAR_0600 | MMAR_1298 | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | Thymidylate kinase Tmk; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.479 |
dut | MMAR_2016 | MMAR_2017 | MMAR_2016 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved hypothetical membrane protein. | 0.780 |
dut | MMAR_2018 | MMAR_2017 | MMAR_2018 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved hypothetical protein. | 0.874 |
dut | MMAR_3773 | MMAR_2017 | MMAR_3773 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Conserved protein; Function unknown but N-term contains a bulb-type mannose-specific lectin and C-term contains a LysM, a putative peptidoglycan-binding domain. | 0.778 |
dut | dcd | MMAR_2017 | MMAR_0600 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Deoxycytidine triphosphate deaminase, Dcd; Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate. | 0.933 |
dut | fgd1 | MMAR_2017 | MMAR_0709 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | F420-dependent glucose-6-phosphate dehydrogenase Fgd1; Catalyzes the coenzyme F420-dependent oxidation of glucose 6- phosphate (G6P) to 6-phosphogluconolactone. Appears to have a role in resistance to oxidative stress, via its consumption of G6P that serves as a source of reducing power to combat oxidative stress in mycobacteria. | 0.773 |
dut | ndkA | MMAR_2017 | MMAR_3769 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family. | 0.957 |
dut | thyA | MMAR_2017 | MMAR_1956 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase ThyA; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.967 |
dut | thyA_1 | MMAR_2017 | MMAR_0027 | Deoxyuridine 5'-triphosphate nucleotidohydrolase DutT; This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA; Belongs to the dUTPase family. | Thymidylate synthase, ThyA_1; Involved in deoxyribonucleotide biosynthesis. provides the sole de novo source of dTMP for dana biosynthesis [catalytic activity: 5,10- methylenetetrahydrofolate + dump = dihydrofolate + dTMP]. | 0.963 |