Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
ppnKInorganic polyphosphate/ATP-NAD kinase, PpnK; Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP. (307 aa)    
Predicted Functional Partners:
tlyA
Cytotoxin/hemolysin, TlyA; Has a contact-dependent haemolytic activity; possibly involved in virulence (pore formation).
  
  
 0.985
recN
DNA repair protein, RecN; May be involved in recombinational repair of damaged DNA.
     
 0.962
nadE
Glutamine-dependent NAD(+) synthetase NadE; Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.
    
 0.957
nadD
Nicotinate-nucleotide adenylyltransferase NadD; Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD).
 
 
 0.951
MMAR_2498
Conserved hypothetical protein.
     
 0.930
cobB-3
Transcriptional regulatory protein; Involved in transcriptional mechanism; Belongs to the sirtuin family. Class III subfamily.
  
 
 0.917
pntAa
NAD(P) transhydrogenase (subunit alpha) PntAa; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.912
pntAb
NAD(P) transhydrogenase (subunit alpha) PntAb; The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane [catalytic activity: NADPH + NAD+ = NADP+ + NADH].
     
 0.912
MMAR_2496
Conserved protein.
     
 0.911
MMAR_2497
Phosphatase; Function unknown; probably involved in cellular metabolism.
     
 0.911
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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