STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pknKSerine/threonine-protein kinase transcriptional regulatory protein PknK; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. (1109 aa)    
Predicted Functional Partners:
pstP
Serine/threonine phosphatase PstP; Involved in regulation (using dephosphorylation of a specific phosphorylated substrate).
 
 
 0.808
pknB
Serine/threonine-protein kinase B PknB; Involved in signal transduction (via phosphorylation). thought to regulate cell division/differentiation. can phosphorylate the peptide substrate myelin basic protein (MBP) [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
 
 
0.552
hsp
Heat shock protein Hsp; Thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.544
MMAR_2577
Conserved hypothetical protein.
  
    0.544
MMAR_2991
Molecular chaperone (small heat shock protein); Function unknown. may be involved in a chaperoning process; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.544
hspX_1
Heat shock protein HspX_1; Thought to be involved in the initiation step of translation at high temperature. bound to 30S ribosomal subunit. possibly a molecular chaperone. in M. tuberculosis H37Rv seems to be regulated positively by SigE and negatively by HspR; Belongs to the small heat shock protein (HSP20) family.
  
 
 0.544
pknE
Transmembrane serine/threonine-protein kinase E PknE; Involved in signal transduction (via phosphorylation). thought to be involved in membrane transport [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
 
   
0.528
MMAR_0738
Two-component sensor and regulator.
  
 
 0.514
MMAR_2704
Conserved protein; Function unknown but contains an FHA domain. these domains are involved in nuclear signalling domain and may bind phosphothreonine, phosphoserine and sometimes phosphotyrosine.
 
 
 
 0.506
lpqK
Conserved lipoprotein, LpqK.
 
    0.502
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.