Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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embR_1Transcriptional regulatory protein EmbR_1; Involved in transcriptional mechanism. thought to regulate the biosynthesis of the mycobacterial cell wall arabinan and resistance to ethambutol (Emb; dextro-2,2'- (ethylenediimino)-di-1-butanol), regulating EmbA and EmbB. (379 aa)    
Predicted Functional Partners:
MMAR_3547
Serine/threonine-protein kinase transcriptional regulatory protein; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein]. N-term resembles PknK from MTB.
 
 0.747
echA13
enoyl-CoA hydratase EchA13; May oxidize fatty acids using specific components (by similarity) [catalytic activity: (3S)-3-hydroxyacyl- CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O].
  
   
 0.711
pknK_3
Serine/threonine-protein kinase transcriptional regulatory protein PknK_3; Involved in signal transduction (via phosphorylation). involved in transcriptional regulatory mechanism and in the regulation of secondary metabolites [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
 
 0.702
MMAR_5269
Conserved hypothetical transmembrane protein.
  
     0.666
MMAR_2962
Transcriptional regulatory protein; Involved in transcriptional mechanism.
  
 0.629
MMAR_3544
Conserved hypothetical protein.
       0.618
MMAR_5464
ADP-ribosyltransferse; Related to a family of actin-ADP-ribosylating toxins from bacillus and clostridia hence may play a role in virulence or protection against predation.
 
    0.612
pknH
Transmembrane serine/threonine-protein kinase H PknH; Involved in signal transduction (via phosphorylation). in M. tuberculosis thought to be involved in arabinan metabolism, phosphorylating perhaps EmbR [catalytic activity: ATP + a protein = ADP + a phosphoprotein].
  
 
 
 0.609
MMAR_2832
Conserved hypothetical protein.
  
 0.598
MMAR_3522
Transcriptional regulatory protein (LuxR- family); Involved in transcriptional mechanism.
  
 0.572
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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