STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMAR_4037Transmembrane ATP-binding protein ABC transporter; Thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane. (874 aa)    
Predicted Functional Partners:
MMAR_4036
Transmembrane ATP-binding protein ABC transporter; Thought to be involved in active transport of drugs across the membrane (export): multidrugs resistance by an export mechanism. responsible for energy coupling to the transport system and for the translocation of the substrate across the membrane.
 
 
0.998
mbtB
Phenyloxazoline synthase MbtB; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this peptide synthase forms amide bound between the carboxylic acid of salicylate and the alpha-amino group of serine (serine/threonine ligation).
 
 
 0.958
mbtA
Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins (initiation step of mycobactin chain growth). activates the mycobactin ACP in two half-reactions: activates salicylic acid as acyladenylate (adenylation step) + transfers activated salicylate to the MbtA ACP as a thioester (arylation step).
 
  
 0.855
mbtI
Isochorismate synthase MbtI; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. possibly plays a role in the conversion of chorismate to salicilate (the starter unit for mycobactin siderophore construction).
 
  
 0.793
MMAR_0541
Conserved protein.
 
 
 0.784
MMAR_3176
Non-ribosomal peptide synthetase; Production of unknown peptide. contains 5 predicted modules of domain organiszation:Amt, CAMT, cat, cat, CAMT int te. the 'A' domain substrates have not been accurately predicted but probably Phe, Thr or ala).
  
 
 0.754
MMAR_1180
N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide.
  
 0.746
MMAR_3099
Polyketide synthase and peptide synthetase; Production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP).
  
 0.746
mbtG
lysine-N-oxygenase MbtG; Involved in the biogenesis of the hydroxyphenyloxazoline-containing siderophore mycobactins. this hydroxylase is possibly required for N-hydroxylation of the two lysine residues at some stage during mycobactin assembly [catalytic activity: L-lysine + O(2) = N6-hydroxy- L-lysine + H(2)O. no information can be found if this enzyme is NADPH dependent or independent].
 
  
 0.741
MMAR_0101
Polyketide synthase PKS; Function unknown but contains a single extension module with domain structure (KS, Ata, DH, KR, ACP).
  
 0.727
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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