STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
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Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
MMAR_4079Adenylate cyclase; Thought to play a role in regulation of cellular metabolism by catalysing the synthesis of a second messenger, camp [catalytic activity: ATP = 3',5'-cyclic AMP + pyrophosphate]. (534 aa)    
Predicted Functional Partners:
pykA
Pyruvate kinase PykA; Produces phosphoenol pyruvate in glycolysis [catalytic activity : ATP + pyruvate = ADP + phosphoenolpyruvate]; Belongs to the pyruvate kinase family.
  
 0.921
cpdA
Conserved hypothetical protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
  
 
 0.910
ndkA
Nucleoside diphosphate kinase NdkA; Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate; Belongs to the NDK family.
    
 0.909
relA
GTP pyrophosphokinase RelA; In eubacteria ppGpp (guanosine 3'-diphosphate 5-' diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance.
    
 0.902
moaA2
Molybdenum cofactor biosynthesis protein A2 MoaA2; Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8- dihydroguanosine 5'-triphosphate.
  
 0.834
MMAR_0738
Two-component sensor and regulator.
  
 
 0.795
MMAR_0333
Conserved hypothetical transmembrane protein.
 
 0.751
MMAR_3042
Conserved hypothetical protein; Function unknown. contains adenylate cyclase domain.
 
   
 0.735
MMAR_1265
Sensor part of the two-component regulatory system.
  
 
 0.718
MMAR_0730
Adenylylate/guanylate cyclase; Function unknown but contains a N-term CheY-like response regulator receiver domain and C-term adenylyl/guanylyl cyclase catalytic domain.
 
 
0.713
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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