STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
sbcDDNA repair exonuclease SbcD; Function unknown: possible role in DNA replication, recombination, and repair. (383 aa)    
Predicted Functional Partners:
polA
DNA polymerase I PolA; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
 0.983
MMAR_3599
Involved in chromosome structure and partitioning. essential for chromosome partition. part of phage replication machinery.
  
 0.982
MMAR_4142
Conserved hydrolase; Function unknown, contains P-loop containing nucleoside triphosphate hydrolase superfamily domain.
 
 
 0.966
MMAR_3076
5'-3' exonuclease; Involved in DNA metabolism.
  
 0.811
recA
Recombinase A RecA; Can catalyze the hydrolysis of ATP in the presence of single- stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage; Belongs to the RecA family.
  
 0.796
dinG
ATP-dependent helicase DinG; Probable helicase involved in DNA repair and perhaps also replication.
  
 0.795
MMAR_1151
Conserved hypothetical protein; Function unknown but belongs to the DNA/RNA polymerase superfamily.
  
 
 0.781
sixA
Phosphohistidine phosphatase SixA; Function unknown, possible role in signal transduction.
     
 0.719
topA
DNA topoisomerase I TopA; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA [...]
  
 0.707
MMAR_4141
Dehydrogenase fad flavoprotein Gmc oxidoreductase; Function unknown, probably involved in cellular metabolism, probably electron-transfer-linked.
  
    0.690
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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