Nodes:
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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from curated databases
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
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[Homology]
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fadD6fatty-acid-CoA ligase FadD6; Function unknown, but supposed involvement in lipid degradation. (593 aa)    
Predicted Functional Partners:
pks15/1
Polyketide synthase Pks15/1; Catalyzes the elongation by iterative transfer of p- hydroxybenzoyl group from FadD22 (pHBA-S-FAdD22) to form p- hydroxyphenylalkanoate (pHPA) intermediates during phenolphthiocerol (PPOL) biosynthesis. PPOL is an important intermediate in the biosynthesis of phenolic glycolipid (mycosid B). Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.
  
 0.892
MMAR_3798
Polyketide synthase involved in lipid synthesis. three extension modules, domain arrangement: KS, Ata, DH, ER, KR, ACP; KS ATP, KR, ACP; KS ATP, DH, KR, ACP.
  
 0.892
MMAR_1180
N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide.
  
 0.853
ppsC
Phenolpthiocerol synthesis type-I polyketide synthase PpsC; Involved in phenolpthiocerol and phthiocerol dimycocerosate (dim) biosynthesis: extension with Malony CoA (complete reduction).
  
 0.853
pks5
Probable polyketide synthase Pks5; Synthesis of unknown metabolite. single module with the following domains: KS, ATP, ER, KR, ACP.
  
 0.853
pks5_1
Polyketide synthase, Pks5_1; Function unknown, catalyzes the elongation of N- fatty acyl-CoA with methylamalonyl-CoA. single module with domain structure: KS, ATP, DH, ER, KR, ACP.
  
 0.853
pks8
Polyketide synthase, Pks8; Function unknown. contains acyl transferase, dehydratase, ketoreductase, and phosphopantetheine attachment site.
  
 0.853
pks12
Polyketide synthase, Pks12; Required for mycoketide synthesis.
  
 0.853
MMAR_3099
Polyketide synthase and peptide synthetase; Production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP).
  
 0.853
MMAR_3098
Polyketide synthase PKS; A single module PKS, with the following domain structure when linked with U/S and D/S ORFs: (KS, ATProp, DH, ER, KR, ACP).
  
 0.842
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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