STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
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[Homology]
Score
purHBifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide]. (523 aa)    
Predicted Functional Partners:
purN
5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 0.999
purB
Adenylosuccinate lyase, PurB; Involved in de novo purine biosynthesis (at the eight step) catalytic activity: 1-(5-phosphoribosyl)-4-(N- succino-carboxamide) -5-aminoimidazole = fumarate + 5'- phosphoribosyl-5-amino-4-imidazolecarboxamide (also catalyzes: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.995
purA
Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
 
 0.988
purD
Phosphoribosylamine-glycine ligase, PurD; Involved in de novo purine biosynthesis (at the second step) [catalytic activity: ATP + 5- phosphoribosylamine + glycine = ADP + phosphate + 5'- phosphoribosylglycinamide]; Belongs to the GARS family.
 
 
 0.986
glyA2
Serine hydroxymethyltransferase GlyA2; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.984
glyA1
Serine hydroxymethyltransferase 1 GlyA1; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
  
 0.984
purF
Amidophosphoribosyltransferase, PurF; Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.
 
 
 0.983
purT
Formate-dependent phosphoribosylglycinamide formyltransferase PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family.
 
 
 0.981
purM
5'-phosphoribosyl-5-aminoimidazole synthetase, PurM; Involved in de novo purine biosynthesis (at the fifth step) [catalytic activity: ATP + 5'- phosphoribosylformylglycinamidine = ADP + phosphate + 5'- phosphoribosyl-5-aminoimidazole].
 
  
 0.980
folD
Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate.
  
 
 0.978
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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