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Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
white nodes:
second shell of interactors
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proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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purCPhosphoribosylaminoimidazole- succinocarboxamide synthase, PurC; Involved in de novo purine biosynthesis (at the seventh step) [catalytic activity: ATP + 1-(5- phosphoribosyl)-4-carboxy-5-aminoimidazole + l-aspartate = ADP + phosphate + 1-(5-phosphoribosyl)-4-(N-succino- carboxamide)-5-aminoimidazole]; Belongs to the SAICAR synthetase family. (297 aa)    
Predicted Functional Partners:
purB
Adenylosuccinate lyase, PurB; Involved in de novo purine biosynthesis (at the eight step) catalytic activity: 1-(5-phosphoribosyl)-4-(N- succino-carboxamide) -5-aminoimidazole = fumarate + 5'- phosphoribosyl-5-amino-4-imidazolecarboxamide (also catalyzes: N6-(1,2-dicarboxyethyl)AMP = fumarate + AMP); Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.
  
 0.999
purD
Phosphoribosylamine-glycine ligase, PurD; Involved in de novo purine biosynthesis (at the second step) [catalytic activity: ATP + 5- phosphoribosylamine + glycine = ADP + phosphate + 5'- phosphoribosylglycinamide]; Belongs to the GARS family.
 
 0.999
purE
Phosphoribosylaminoimidazole carboxylase catalytic subunit PurE (air carboxylase) (AirC); Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
 
 
 0.995
purM
5'-phosphoribosyl-5-aminoimidazole synthetase, PurM; Involved in de novo purine biosynthesis (at the fifth step) [catalytic activity: ATP + 5'- phosphoribosylformylglycinamidine = ADP + phosphate + 5'- phosphoribosyl-5-aminoimidazole].
 
 
 0.992
purK
Phosphoribosylaminoimidazole carboxylase ATPase subunit PurK (air carboxylase) (AirC); Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
 
 0.991
purN
5'-phosphoribosylglycinamide formyltransferase PurN; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.
 
 
 0.991
purH
Bifunctional purine biosynthesis protein PurH; Involved in de novo purine biosynthesis (at the ninth and tenth steps) [catalytic activity 1: 10- formyltetrahydrofolate + 5'-phosphoribosyl-5-amino-4- imidazolecarboxamide = tetrahydrofolate + 5'- phosphoribosyl-5-formamido-4-imidazolecarboxamide] [catalytic activity 2: imp + H2O = 5-formamido-1-(5- phosphoribosyl)imidazole-4-carboxamide].
  
 
 0.985
purL
Phosphoribosylformylglycinamidine synthase II, PurL; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to a [...]
  
 
 0.985
purA
Adenylosuccinate synthetase PurA; Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP; Belongs to the adenylosuccinate synthetase family.
  
 
 0.968
purT
Formate-dependent phosphoribosylglycinamide formyltransferase PurT; Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. Belongs to the PurK/PurT family.
  
 
 0.958
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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