Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
bioF28-amino-7-oxononanoate synthase BioF2; Could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2]. (414 aa)    
Predicted Functional Partners:
bioA
Adenosylmethionine-8-amino-7-oxononanoate aminotransferase, BioA; Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily.
 
 
 0.971
bioF1
8-amino-7-oxononanoate synthase BioF1; Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide.
  
  
 
0.925
bioF2_4
8-amino-7-oxononanoate synthase BioF2_4; Could be involved in biotin biosynthesis (at the first step) [catalytic activity: 6-carboxyhexanoyl-CoA + L- alanine = 8-amino-7-oxononanoate + CoA + CO2].
  
  
 
0.921
bioD
Dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring.
 
  
 0.857
bioB
Biotin synthase BioB; Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family.
 
  
 0.713
MMAR_4969
Acyl carrier protein; Probable role in the biosynthesis of the product from U/S PKS gene, carrying its acyl intermediates.
  
 
 0.630
echA13_1
enoyl-CoA hydratase EchA13_1; Could possibly oxidizes fatty acids using specific components (by similarity) [catalytic activity: (3S)-3- hydroxyacyl-CoA = TRANS-2(or 3)-enoyl-CoA + H(2)O].
  
  0.621
MMAR_1180
N-term fused in-frame with fatty acyl-AMP ligase FadD28_1; Synthesis of unknown polyketide.
  
 
 0.560
MMAR_3099
Polyketide synthase and peptide synthetase; Production of unknown metabolite. this CDS encodes a single NRP and PKS module with domain structure: (KS, Ata, DH, ER, KR, ACP).
  
 
 0.560
fas
Involved in lipid metabolism. fatty acid synthase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH.
  
 0.559
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
Server load: low (22%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.