STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
pcnAPoly(a) polymerase PcnA; Involved in transcription mechanism [catalytic activity: N ATP + (nucleotide)(M) = N diphosphate + (nucleotide)(M+N)]; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. (481 aa)    
Predicted Functional Partners:
gpsI
Bifunctional protein polyribonucleotide nucleotidyltransferase GpsI; Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'- direction.
 
 
 0.919
rphA
Ribonuclease RphA; Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation.
  
  
 0.861
orn
Oligoribonuclease Orn; 3'-to-5' exoribonuclease specific for small oligoribonucleotides; Belongs to the oligoribonuclease family.
 
   
 0.851
MMAR_5470
Conserved hypothetical protein.
     
 0.842
dapB
Dihydrodipicolinate reductase DapB; Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.
  
    0.773
rnz
Metal-dependent hydrolase; Zinc phosphodiesterase, which displays some tRNA 3'- processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA; Belongs to the RNase Z family.
  
  
 0.761
MMAR_5472
Conserved hypothetical protein; Belongs to the Nudix hydrolase family.
       0.757
MMAR_5473
Conserved hypothetical secreted protein.
       0.757
MMAR_5474
Conserved transmembrane protein.
       0.683
sigM
The sigma factor is an initiation factor that promotes attachment of the RNA polymerase to specific initiation sites and then is released; Belongs to the sigma-70 factor family. ECF subfamily.
     
 0.658
Your Current Organism:
Mycobacterium marinum
NCBI taxonomy Id: 216594
Other names: M. marinum M, Mycobacterium marinum M, Mycobacterium marinum str. M, Mycobacterium marinum strain M
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