Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
polXDNA polymerase/3'-5' exonuclease PolX; Derived by automated computational analysis using gene prediction method: Protein Homology. (570 aa)    
Predicted Functional Partners:
lig-2
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
 0.964
fen
Flap endonuclease-1; Structure-specific nuclease with 5'-flap endonuclease and 5'- 3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. A [...]
   
 0.873
APH38351.1
Exodeoxyribonuclease III; Derived by automated computational analysis using gene prediction method: Protein Homology.
    
 0.846
lig
DNA ligase; DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair.
 
 0.837
pcn
DNA polymerase sliding clamp; Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.
    
 0.816
APH39759.1
3'-phosphoesterase; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.799
APH39375.1
Rhomboid family intramembrane serine protease; Derived by automated computational analysis using gene prediction method: Protein Homology.
 
    0.771
APH38691.1
Hypothetical protein; Derived by automated computational analysis using gene prediction method: Protein Homology.
       0.575
APH38673.1
DNA polymerase elongation subunit; Derived by automated computational analysis using gene prediction method: Protein Homology.
  
 0.558
nth-2
Endonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate.
     
 0.545
Your Current Organism:
Methanohalophilus halophilus
NCBI taxonomy Id: 2177
Other names: DSM 3094, INMI Z-7982, Methanihalophilus halophilus, Methanococcus halophilus, OCM 160, Z-7982
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