node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPSY_0010 | BPSY_0014 | BPSY_0010 | BPSY_0014 | Pyruvate oxidase; Belongs to the TPP enzyme family. | Acetolactate synthase small subunit. | 0.983 |
BPSY_0010 | BPSY_0015 | BPSY_0010 | BPSY_0015 | Pyruvate oxidase; Belongs to the TPP enzyme family. | Acetolactate synthase large subunit. | 0.781 |
BPSY_0010 | BPSY_1639 | BPSY_0010 | BPSY_1639 | Pyruvate oxidase; Belongs to the TPP enzyme family. | Glutamate synthase. | 0.495 |
BPSY_0010 | ilvC | BPSY_0010 | BPSY_0705 | Pyruvate oxidase; Belongs to the TPP enzyme family. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.857 |
BPSY_0010 | ilvD | BPSY_0010 | BPSY_1316 | Pyruvate oxidase; Belongs to the TPP enzyme family. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.666 |
BPSY_0010 | leuA | BPSY_0010 | BPSY_0831 | Pyruvate oxidase; Belongs to the TPP enzyme family. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.783 |
BPSY_0010 | leuB | BPSY_0010 | BPSY_0070 | Pyruvate oxidase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.724 |
BPSY_0010 | leuC | BPSY_0010 | BPSY_0105 | Pyruvate oxidase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.785 |
BPSY_0010 | leuD | BPSY_0010 | BPSY_0104 | Pyruvate oxidase; Belongs to the TPP enzyme family. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.813 |
BPSY_0014 | BPSY_0010 | BPSY_0014 | BPSY_0010 | Acetolactate synthase small subunit. | Pyruvate oxidase; Belongs to the TPP enzyme family. | 0.983 |
BPSY_0014 | BPSY_0015 | BPSY_0014 | BPSY_0015 | Acetolactate synthase small subunit. | Acetolactate synthase large subunit. | 0.999 |
BPSY_0014 | BPSY_0190 | BPSY_0014 | BPSY_0190 | Acetolactate synthase small subunit. | Pyruvate oxidase, PoxB; Belongs to the TPP enzyme family. | 0.983 |
BPSY_0014 | BPSY_1639 | BPSY_0014 | BPSY_1639 | Acetolactate synthase small subunit. | Glutamate synthase. | 0.836 |
BPSY_0014 | ilvC | BPSY_0014 | BPSY_0705 | Acetolactate synthase small subunit. | Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate. | 0.999 |
BPSY_0014 | ilvD | BPSY_0014 | BPSY_1316 | Acetolactate synthase small subunit. | Dihydroxy-acid dehydratase; Belongs to the IlvD/Edd family. | 0.858 |
BPSY_0014 | leuA | BPSY_0014 | BPSY_0831 | Acetolactate synthase small subunit. | 2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. | 0.985 |
BPSY_0014 | leuB | BPSY_0014 | BPSY_0070 | Acetolactate synthase small subunit. | 3-isopropylmalate dehydrogenase; Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily. | 0.990 |
BPSY_0014 | leuC | BPSY_0014 | BPSY_0105 | Acetolactate synthase small subunit. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.794 |
BPSY_0014 | leuD | BPSY_0014 | BPSY_0104 | Acetolactate synthase small subunit. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.857 |
BPSY_0015 | BPSY_0010 | BPSY_0015 | BPSY_0010 | Acetolactate synthase large subunit. | Pyruvate oxidase; Belongs to the TPP enzyme family. | 0.781 |