node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
BPSY_0494 | BPSY_1322 | BPSY_0494 | BPSY_1322 | Threonine dehydratase. | Phosphoserine phosphatase. | 0.912 |
BPSY_0494 | BPSY_1629 | BPSY_0494 | BPSY_1629 | Threonine dehydratase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.461 |
BPSY_0494 | glyA | BPSY_0494 | BPSY_1436 | Threonine dehydratase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.958 |
BPSY_0841 | BPSY_1270 | BPSY_0841 | BPSY_1270 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Purl. | 0.964 |
BPSY_0841 | BPSY_1629 | BPSY_0841 | BPSY_1629 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.583 |
BPSY_0841 | fmt | BPSY_0841 | BPSY_1321 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.607 |
BPSY_0841 | folD | BPSY_0841 | BPSY_1705 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.997 |
BPSY_0841 | glyA | BPSY_0841 | BPSY_1436 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.974 |
BPSY_0841 | purH | BPSY_0841 | BPSY_1561 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.981 |
BPSY_0841 | thyA | BPSY_0841 | BPSY_1098 | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.613 |
BPSY_1270 | BPSY_0841 | BPSY_1270 | BPSY_0841 | Purl. | Formate-tetrahydrofolate ligase; Belongs to the formate--tetrahydrofolate ligase family. | 0.964 |
BPSY_1270 | fmt | BPSY_1270 | BPSY_1321 | Purl. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.871 |
BPSY_1270 | folD | BPSY_1270 | BPSY_1705 | Purl. | Methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.820 |
BPSY_1270 | gcvH | BPSY_1270 | BPSY_0067 | Purl. | Glycine cleavage system H protein; The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein. | 0.652 |
BPSY_1270 | glyA | BPSY_1270 | BPSY_1436 | Purl. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
BPSY_1270 | purH | BPSY_1270 | BPSY_1561 | Purl. | Bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase. | 0.995 |
BPSY_1322 | BPSY_0494 | BPSY_1322 | BPSY_0494 | Phosphoserine phosphatase. | Threonine dehydratase. | 0.912 |
BPSY_1322 | BPSY_1629 | BPSY_1322 | BPSY_1629 | Phosphoserine phosphatase. | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | 0.476 |
BPSY_1322 | glyA | BPSY_1322 | BPSY_1436 | Phosphoserine phosphatase. | Glycine/serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
BPSY_1629 | BPSY_0494 | BPSY_1629 | BPSY_0494 | 5,10-methylenetetrahydrofolate reductase; Belongs to the methylenetetrahydrofolate reductase family. | Threonine dehydratase. | 0.461 |